General
Preferred name
BREXPIPRAZOLE
Synonyms
OPC-34712 ()
Rexulti ()
Brexpiprazole-d8 ()
P&D ID
PD009042
CAS
913611-97-9
1427049-21-5
Tags
available
drug
Approved by
PMDA
EMA
FDA
First approval
2015
Drug Status
investigational
approved
Drug indication
Major depressive disorder
Max Phase
Phase 4
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Brexpiprazole is a serotonin-dopamine activity modulator (SDAM) .
(GtoPdb)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
0
Organisms
1
Compound Sets
18
AdooQ Bioactive Compound Library
ChEMBL Approved Drugs
ChEMBL Drugs
Drug Repurposing Hub
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
Enamine BioReference Compounds
EU-OPENSCREEN Bioactive Compound Library
Guide to Pharmacology
MedChem Express Bioactive Compound Library
NCATS Inxight Approved Drugs
ReFrame library
TargetMol Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
33
Molecular Weight
433.18
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
1
Rotatable Bonds
7
Ring Count
5
Aromatic Ring Count
4
cLogP
4.72
TPSA
48.57
Fraction CSP3
0.32
Chiral centers
0.0
Largest ring
6.0
QED
0.43
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
GPCR/G protein
Neuroscience
Neuronal Signaling
Target
5-HT1A
5-HT2A
??1B-adrenergic receptor
??2C receptors
D2L
DRD2
5-HT Receptor
Adrenergic Receptor
Dopamine Receptor
Indication
depression, schizophrenia
MOA
dopamine receptor partial agonist
Source data
