General
Preferred name
OXYGEN
Synonyms
Oxygenium ()
Oxygen 93 percent ()
E948 ()
Medicinal oxygen air liquide sante ()
Molecular oxygen ()
E-948 ()
Dioxygen ()
INS-948 ()
INS NO.948 ()
Oxygen molecule ()
RNS60 COMPONENT OXYGEN ()
RNS-60 COMPONENT OXYGEN ()
P&D ID
PD009034
CAS
12185-07-8
1338-93-8
7782-44-7
Tags
inorganic
drug
Approved by
FDA
Drug Status
approved
vet_approved
Max Phase
4.0
Drug indication
Gas, Medicinal
First approval
2006
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PHARMACODYNAMICS
Oxygen therapy improves effective cellular oxygenation, even at a low rate of tissue perfusion. Oxygen molecules adjust hypoxic ventilatory drive by acting on chemoreceptors on carotid bodies that sequentially relay sensory information to the higher processing centers in brainstem. It also attenuates hypoxia-induced mitochondrial depolarization that generates reactive oxygen species and/or apoptosis.; Studies investigating on hyperbaric oxygen therapy has shown that oxygen supplementation can induce neural stem cell proliferation in neonatal rats thus promoting neurological regeneration after injuries [A19117]. CD34+, CD45-dim leukocytes are also potential targets for hyperbaric oxygen therapy benefit as their mobilization was increased in vitro which could facilitate the acceleration of recovery at peripheral sites [A19113].
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
7
ChEMBL Approved Drugs
ChEMBL Drugs
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
NCATS Inxight Approved Drugs
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
45
Molecular Weight
31.99
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
0
Rotatable Bonds
0
Ring Count
0
Aromatic Ring Count
0
cLogP
0.07
TPSA
34.14
Fraction CSP3
0.0
Chiral centers
0.0
Largest ring
0.0
QED
0.38
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Source data
