General
Preferred name
SINCALIDE
Synonyms
SQ19844 ammonium ()
CCK-8 ammonium ()
Cholecystokinin octapeptide ammonium ()
CCK-8 ()
Sincalide (ammonium) ()
Cholecystokinin octapeptide ()
SQ19844 ()
Cholecystokinin octapeptide (ammonium) ()
CCK-8 (ammonium) ()
SQ19844 (ammonium) ()
Cholecystokinin Octapeptide, CCK-OP, CCK-8, SQ 19,844 ()
CCK Octapeptide (Sincalide) ()
Sincalide ammonium ()
Cholecystokinin c-terminal octapeptide ()
Kinevac ()
Sincalida ()
Cck c-terminal octapeptide ()
SQ 19844 ()
SQ-19844 ()
Cck-8s ()
CCK Octapeptide (sulfated) (sodium salt) ()
CCK Octapeptide (sulfated) (ammonium salt) ()
P&D ID
PD009033
CAS
25126-32-3
70706-98-8
Tags
available
drug
Approved by
FDA
First approval
1976
Drug Status
approved
Max Phase
4.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
MOA
When injected intravenously, sincalide produces a substantial reduction in gallbladder size by causing this organ to contract. The evacuation of bile that results is similar to that which occurs physiologically in response to endogenous cholecystokinin. Like cholecystokinin, sincalide stimulates pancreatic secretion; concurrent administration with secretin increases both the volume of pancreatic secretion and the output of bicarbonate and protein (enzymes) by the gland. This combined effect of secretin and sincalide permits the assessment of specific pancreatic function through measurement and analysis of the duodenal aspirate.
DESCRIPTION
The sulphated form of CCK-8. A synthetic variant, desulphated CCK-8 also exists.
(GtoPdb)
DESCRIPTION
Sincalide ammonium (CCK-8 ammonium) is a potent analog of the amino acid peptide hormone cholecystokinin (CCK), an active fragment that retains much of the biological activity of CCK.Sincalide ammonium promotes bile secretion, causes gallbladder contractions and relaxes the sphincter of Oddi, thereby facilitating bile drainage into the duodenum. Sincalide ammonium promotes bile secretion, contraction of the gallbladder and relaxation of the sphincter of Oddi, thereby facilitating the drainage of bile into the duodenum.Sincalide ammonium can be injected to promote gallbladder contraction, and is commonly used as an adjunct in the diagnosis of gallbladder and pancreatic diseases and in cholecystography.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
1
Organisms
2
Compound Sets
14
ChEMBL Approved Drugs
ChEMBL Drugs
Drug Repurposing Hub
DrugCentral
DrugCentral Approved Drugs
DrugMAP
Guide to Pharmacology
LSP-MoA library (Laboratory of Systems Pharmacology)
NCATS Inxight Approved Drugs
ReFrame library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
42
Molecular Weight
1142.35
Hydrogen Bond Acceptors
16
Hydrogen Bond Donors
13
Rotatable Bonds
33
Ring Count
4
Aromatic Ring Count
4
cLogP
-1.33
TPSA
426.8
Fraction CSP3
0.39
Chiral centers
7.0
Largest ring
6.0
QED
0.02
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
CCK
Akt
Apoptosis
Cholecystokinin Receptor
PI3K
MOA
cholecystokinin agonist
Pathway
GPCR/G protein
Neuronal Signaling
PI3K/Akt/mTOR
Source data
