General
Preferred name
NITROGEN
Synonyms
Molecular nitrogen ()
Nitrogen (n2) ()
INS-941 ()
INS NO.941 ()
E941 ()
Nitrogen, liquid ()
Dinitrogen ()
Nitrogen gas ()
E-941 ()
P&D ID
PD009023
CAS
156457-45-3
7727-37-9
Tags
inorganic
drug
Approved by
FDA
Drug Status
approved
vet_approved
Max Phase
Phase 4
Drug indication
Pharmaceutic Aid (air displacement)
First approval
2015
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
MOA In cryotherapy, mechanism of action could be classified into three stages: 1. heat transfer, 2. cell injury and 3. inflammation.; Boiling point of liquid nitrogen is -196°C, which is the responsible for creating the initial stage which is heat transfer. The second stage is cell injury which is induced during thawing conditions of the cells. The last step in the cryotherapy is the inflammation stage which is characterized by edema and erythema. Inflammation occurs as a result of cellular death and it helps in local cell destruction.
TOXICITY Liquid nitrogen:; Serious adverse effects include hemorrhage, infection, and excessive granulation tissue formation.; Alopecia, atrophy, keloids, scarring, hypopigmentation, and ectropion formation are among permanent complications of cryotherapy.; ;
Compound Sets
7
ChEMBL Approved Drugs
CHEMBL142438
ChEMBL Drugs
CHEMBL142438
DrugBank
DB09152
DrugBank Approved Drugs
DB09152
DrugCentral
4251
DrugCentral Approved Drugs
4251
NCATS Inxight Approved Drugs
N762921K75
External IDs
28
Properties
(calculated by RDKit )
Molecular Weight
28.01
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
0
Rotatable Bonds
0
Ring Count
0
Aromatic Ring Count
0
cLogP
0.03
TPSA
47.58
Fraction CSP3
0.0
Chiral centers
0.0
Largest ring
0.0
QED
0.35
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Source data