General
Preferred name
DEXKETOPROFEN
Synonyms
RP-19583 ()
Dexketoprofen(S)-Ketoprofen ()
Dexketoprofen (trometamol) ()
S-(+)-Ketoprofen ()
Dexketoprofen (tromethamine salt) ()
(S)-Ketoprofen ()
Actron, (S)-Ketoprofen, Dexketoprofen ()
Arveles ()
Keral ()
Ketoprofen, (s)- ()
P&D ID
PD009002
CAS
22161-81-5
156604-79-4
Tags
natural product
drug
available
Drug Status
investigational
approved
Max Phase
Phase 4
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
METABOLISM
Dexketoprofen is highly lipophilic, and is metabolized in the liver by glucuronidation [L1304]. In one study, after oral administration of 25 mg of dexketoprofen to young healthy adults, Tmax was approximately 30 min for a Cmax of 3.7 ± 0.72 mg/l [L1305]. Dexketoprofen trometamol is metabolized by the hepatic cytochrome P450 enzymes (CYP2C8 and CYP2C9) [L1305]. ; ; Dexketoprofen trometamol has a number of metabolites, with hydroxyl derivatives making up the greatest volume [L1305]. In humans, hydroxylation plays a minor role. ; ; Dexketoprofen is primarily conjugated to an acyl-glucuronide [L1305]
TOXICITY
Nausea and/or vomiting, stomach pain, diarrhea, digestive problems (dyspepsia) are the most common symptoms of toxicity. More toxicity symptoms include dizziness, sleepiness, disturbed sleep, nervousness, headache, palpitations, flushing, stomach problems, constipation, dry mouth, flatulence, skin rash, tiredness, pain, feeling feverish and shivering, and malaise.; ; Severe toxicity can lead to thrombocytopenia and anemia with bleeding episodes. Dexketoprofen is associated with a small increased risk of myocardial infarction [L1302].;
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
11
Cayman Chemical Bioactives
ChEMBL Approved Drugs
ChEMBL Drugs
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
LSP-MoA library (Laboratory of Systems Pharmacology)
NPC Screening Collection
Selleckchem Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
39
Molecular Weight
254.09
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
1
Rotatable Bonds
4
Ring Count
2
Aromatic Ring Count
2
cLogP
3.11
TPSA
54.37
Fraction CSP3
0.12
Chiral centers
1.0
Largest ring
6.0
QED
0.85
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
Immunology/Inflammation
Target
COX
Source data
