General
Preferred name
DEXKETOPROFEN
Synonyms
RP-19583 ()
(S)-(+)-Ketoprofen ()
(S)-Ketoprofen ()
Dexketoprofen(S)-Ketoprofen ()
Dexketoprofen (trometamol) ()
S-(+)-Ketoprofen ()
Dexketoprofen (tromethamine salt) ()
Actron, (S)-Ketoprofen, Dexketoprofen ()
Dexketoprofen trometamol ()
Dexketoprofeno ()
Dexketoprofene ()
Ketoprofen, (s)- ()
Keral ()
Arveles ()
P&D ID
PD009002
CAS
22161-81-5
156604-79-4
Tags
available
drug
Drug Status
approved
investigational
Max Phase
4.0
Drug indication
rheumatic disease
First approval
1994
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
TOXICITY Nausea and/or vomiting, stomach pain, diarrhea, digestive problems (dyspepsia) are the most common symptoms of toxicity. More toxicity symptoms include dizziness, sleepiness, disturbed sleep, nervousness, headache, palpitations, flushing, stomach problems, constipation, dry mouth, flatulence, skin rash, tiredness, pain, feeling feverish and shivering, and malaise.; ; Severe toxicity can lead to thrombocytopenia and anemia with bleeding episodes. Dexketoprofen is associated with a small increased risk of myocardial infarction [L1302].;
METABOLISM Dexketoprofen is highly lipophilic, and is metabolized in the liver by glucuronidation [L1304]. In one study, after oral administration of 25 mg of dexketoprofen to young healthy adults, Tmax was approximately 30 min for a Cmax of 3.7 ± 0.72 mg/l [L1305]. Dexketoprofen trometamol is metabolized by the hepatic cytochrome P450 enzymes (CYP2C8 and CYP2C9) [L1305]. ; ; Dexketoprofen trometamol has a number of metabolites, with hydroxyl derivatives making up the greatest volume [L1305]. In humans, hydroxylation plays a minor role. ; ; Dexketoprofen is primarily conjugated to an acyl-glucuronide [L1305]
DESCRIPTION S-(+)-Ketoprofen is a potent inhibitor of both COX-1 and COX-2 with IC50s of 1.9 and 27 nM, respectively.
PRICE 29
DESCRIPTION Dexketoprofen trometamol (Dexketoprofen tromethamine salt) is an orally active non-selective COX inhibitor. Dexketoprofen trometamol has a pain-relieving effect, anti-inflammatory effect and anti-cancer effect[1][2][3][4][5].
PRICE 51
DESCRIPTION S-(+)-Ketoprofen ((S)-(+)-Ketoprofen) works by blocking the action of a substance in the body called cyclo-oxygenase. It belongs to a class of medicines called non-steroidal anti-inflammatory drugs (NSAIDs). Cyclo-oxygenase is involved in the production of chemicals in the body called prostaglandins. Prostaglandins are produced in response to injury or certain diseases and would otherwise go on to cause swelling, inflammation and pain. By blocking cyclo-oxygenase, S-(+)-Ketoprofen prevents the production of prostaglandins and therefore reduces inflammation and pain. Along with Peripheral analgesic action it possesses central analgesic action.S-(+)-Ketoprofen is a non-steroidal anti-inflammatory drug. It is manufactured by Menarini, under the tradename Keral. It is available in the UK, as S-(+)-Ketoprofen trometamol, as a prescription-only drug and in Latin America as Miracox, produced by Stein in Costa Rica. In Italy it is available as an over the counter-drug under the tradename Enantyum. In Lithuania it is available as over the counter-drug uder tradename Dolmen. (TargetMol Bioactive Compound Library)
DESCRIPTION Dexketoprofen trometamol is a modified non-selective COX inhibitor with a rapid onset of action that is available as both oral and parenteral formulations. (TargetMol Bioactive Compound Library)
Compound Sets
12
Cayman Chemical Bioactives
16407
ChEMBL Approved Drugs
CHEMBL75435
ChEMBL Drugs
CHEMBL75435
DrugBank
DB09214
DrugBank Approved Drugs
DB09214
DrugCentral
833
DrugCentral Approved Drugs
833
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL75435
MedChem Express Bioactive Compound Library
HY-B2137
HY-B0714
NPC Screening Collection
Selleckchem Bioactive Compound Library
s-ketoprofen
TargetMol Bioactive Compound Library
T0839L
T9284
External IDs
43
Properties
(calculated by RDKit )
Molecular Weight
254.09
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
1
Rotatable Bonds
4
Ring Count
2
Aromatic Ring Count
2
cLogP
3.11
TPSA
54.37
Fraction CSP3
0.12
Chiral centers
1.0
Largest ring
6.0
QED
0.85
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
COX-2
COX
COX-1
Pathway
Immunology/Inflammation
Neuroscience
Source data