General
Preferred name
MELPERONE
Synonyms
Melperone hydrochloride ()
Metylperon ()
FG-5111 ()
FG 5111 ()
Bunil ()
Flubuperone ()
Melperone (hydrochloride) ()
Melperone-d4 (hydrochloride) ()
P&D ID
PD008997
CAS
3575-80-2
1622-79-3
1219798-80-7
Tags
natural product
drug
available
First approval
1972
Drug Status
investigational
approved
Max Phase
Phase 3
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
TOXICITY An overdose of Melperone may result in cardiac arrhythmias [T110, A318622].
DESCRIPTION 5-HT2A/D2 receptor antagonist; neuroleptic (Tocriscreen Plus)
DESCRIPTION 5-HT2A/D2 receptor antagonist; neuroleptic (Tocriscreen Total)
Compound Sets
18
Cayman Chemical Bioactives
19770
31489
ChEMBL Drugs
CHEMBL1531134
Drug Repurposing Hub
DrugBank
DB09224
DrugCentral
1677
DrugCentral Approved Drugs
1677
DrugMatrix
Enamine BioReference Compounds
Ki Database
MELPERONE
Mcule NIBR MoA Box Subset
MCULE-2137542388
MedChem Express Bioactive Compound Library
HY-B2169
NIH Clinical Collections (NCC)
Novartis Chemogenetic Library (NIBR MoA Box)
NPC Screening Collection
ReFrame library
TargetMol Bioactive Compound Library
T7421
Tocriscreen Plus
2495
Tocriscreen Total
External IDs
44
Properties
(calculated by RDKit )
Molecular Weight
263.17
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
0
Rotatable Bonds
5
Ring Count
2
Aromatic Ring Count
1
cLogP
3.52
TPSA
20.31
Fraction CSP3
0.56
Chiral centers
0.0
Largest ring
6.0
QED
0.76
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target Type
7-TM Receptors
Member status
virtual
MOA
DRD2 antagonist
dopamine receptor antagonist, serotonin receptor antagonist
Target
DRD2, HTR2A
Indication
psychosis
Source data