General
Preferred name
ARANIDIPINE
Synonyms
ARANIPIDINE ()
MPC1304 ()
Aranidipino ()
MPC-1304 ()
Sapresta ()
P&D ID
PD008994
CAS
86780-90-7
Tags
available
drug
Drug Status
approved
experimental
investigational
Max Phase
2.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PRICE 53
DESCRIPTION Aranidipine (MPC1304) (MPC1304) is a calcium channel antagonist with potent and long-lasting antihypertensive effects.
DESCRIPTION Aranidipine (MPC-1304) is a long-acting, dihydropyridine-type Ca2+ channel blocker that produces an hypotensive effect in vivo . Activation of K+ channels may also be involved in aranidipine-induced vasodilation, as identified in a rat model . We show the compound with no specified stereochemistry to represent the racemic mixture of enantiomers. It has been reported that the (S) enantiomer of aranidipine is responsible for most of the pharmacological activity of the racemate . (GtoPdb)
Compound Sets
11
Axon Medchem Screening Library
3013
Cayman Chemical Bioactives
40813
ChEMBL Drugs
CHEMBL2104030
DrugBank
DB09229
DrugCentral
234
DrugCentral Approved Drugs
234
DrugMatrix
Guide to Pharmacology
11744
MedChem Express Bioactive Compound Library
HY-U00212
NPC Screening Collection
ReFrame library
External IDs
23
Properties
(calculated by RDKit )
Molecular Weight
388.13
Hydrogen Bond Acceptors
8
Hydrogen Bond Donors
1
Rotatable Bonds
6
Ring Count
2
Aromatic Ring Count
1
cLogP
2.13
TPSA
124.84
Fraction CSP3
0.32
Chiral centers
1.0
Largest ring
6.0
QED
0.45
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
MOA
Calcium Channel
Target
Ca channel antagonist
Pathway
Membrane Transporter/Ion Channel
Neuronal Signaling
Source data