General
Preferred name
piclidenoson
Synonyms
IB-MECA ()
CF-101 ()
P&D ID
PD008953
CAS
152918-18-8
Tags
drug candidate
natural product
available
Drug indication
Plaque psoriasis
Psoriasis vulgaris
Rheumatoid arthritis
Solid tumour/cancer
Drug Status
investigational
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Piclidenoson is a selective agonist of the adenosine A3 receptor. It has anti-inflammatory action which is being investigated for translation to the clinic .
Early investigations revealed anti-cancer effects . (GtoPdb)
Early investigations revealed anti-cancer effects . (GtoPdb)
INDICATION
Investigated for use/treatment in cancer/tumors (unspecified), eye disorders/infections, psoriasis and psoriatic disorders, and rheumatoid arthritis.; Can-Fite BioPharma has reported that by targeting the adenosine A3-receptor, CF101 may also be used to treat Crohn's disease, a serious gastrointestinal disorder.
DESCRIPTION
Muscarinic agonist
(Tocris Bioactive Compound Library)
DESCRIPTION
A3 selective agonist
(Tocriscreen Total)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
18
AdooQ Bioactive Compound Library
Cayman Chemical Bioactives
Concise Guide to Pharmacology 2017/18
Concise Guide to Pharmacology 2019/20
Concise Guide to Pharmacology 2021/22
Concise Guide to Pharmacology 2023/24
Drug Repurposing Hub
DrugBank
DrugMAP
EU-OPENSCREEN Bioactive Compound Library
Guide to Pharmacology
LSP-MoA library (Laboratory of Systems Pharmacology)
MedChem Express Bioactive Compound Library
ReFrame library
TargetMol Bioactive Compound Library
Tocris Bioactive Compound Library
Tocriscreen Total
ZINC Tool Compounds
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
26
Molecular Weight
510.05
Hydrogen Bond Acceptors
9
Hydrogen Bond Donors
4
Rotatable Bonds
5
Ring Count
4
Aromatic Ring Count
3
cLogP
0.41
TPSA
134.42
Fraction CSP3
0.33
Chiral centers
4.0
Largest ring
6.0
QED
0.36
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
GPCR/G protein
Apoptosis
Target
A3
ADORA1, ADORA2A, ADORA2B, ADORA3
Adenosine Receptor
Primary Target
Adenosine A3 Receptors
MOA
Agonist
Adenosine Receptor agonist
Source data
