General
Preferred name
ELESCLOMOL
Synonyms
STA-4783 ()
Elesclomol (STA-4783) ()
GSK-842879A ()
STA4783 ()
GSK-842879 ()
P&D ID
PD008949
CAS
488832-69-5
Tags
available
drug candidate
Drug Status
investigational
Max Phase
3.0
Drug indication
Neoplasm
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Elesclomol (STA-4783) is a potent copper ionophore and promotes copper-dependent cell death (cuproptosis). Elesclomol specifically binds ferredoxin 1 (FDX1) ¦Á2/¦Á3 helices and ¦Â5 strand. Elesclomol inhibits FDX1-mediated Fe-S cluster biosynthesis. Elesclomol is an oxidative stress inducer that induces cancer cell apoptosis. Elesclomol is a reactive oxygen species (ROS) inducer. Elesclomol can be used for Menkes and associated disorders of hereditary copper deficiency research[1][2][3][4].
PRICE
49
DESCRIPTION
Elesclomol (STA-4783) is an oxidative stress inducer and a highly lipophilic copper ion carrier. Elesclomol induces apoptosis in tumor cells and is used in copper death related studies. Elesclomol also inhibits FDX1-mediated Fe-S cluster biosynthesis.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
579
Organisms
0
Compound Sets
10
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Cayman Chemical Bioactives
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Welcome Trust Cancer Drugs
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
27
Molecular Weight
400.1
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
2
Rotatable Bonds
4
Ring Count
2
Aromatic Ring Count
2
cLogP
2.05
TPSA
64.68
Fraction CSP3
0.16
Chiral centers
0.0
Largest ring
6.0
QED
0.47
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
Apoptosis
Cuproptosis
Reactive Oxygen Species (ROS)
HSP70
Reactive Oxygen Species
HSPA1A
Apoptosis related,HSP (HSP90)
MOA
Oxidative stress inducer
Pathway
Immunology/Inflammation
Metabolic Enzyme/Protease
NF-κB
Cytoskeletal Signaling
Metabolism
NF-¦ÊB
Source data
