General
Preferred name
ESMIRTAZAPINE
Synonyms
MIRTAZAPINE ()
(S)-6-Azamianserin ()
(S)-Org3770 ()
(S)-Mirtazapine ()
ESMIRTAZAPINE MALEATE ()
Mirtazapine, (s)- ()
(s)-org 3770 ()
Esmirtazapina ()
ORG-44-20 ()
ORG 50081 ()
Mirtazapine maleate, (s)- ()
ORG-50081 ()
P&D ID
PD008921
CAS
61337-87-9
680993-85-5
Tags
available
drug candidate
Drug Status
investigational
Max Phase
3.0
Drug indication
Insomnia
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION (S)-Mirtazapine ((S)-Org3770) is a S(+)-enantiomer of Mirtazapine with pronociceptive properties in an animal model of acute thermal nociception. (S)-Mirtazapine is a stereoselective 5-HT2 receptor antagonist. (S)-Mirtazapine is metabolized by CYP2D6 and CYP1A2[1].
PRICE 127
DESCRIPTION (S)-Mirtazapine ((S)-Org3770) is the S(+)-enantiomer of Mirtazapine, functioning as a selective 5-HT2 receptor antagonist with pro-nociceptive effects. It is commonly used in combination with the R(-)-enantiomer of Mirtazapine to study depression. (TargetMol Bioactive Compound Library)
Compound Sets
5
ChEMBL Drugs
CHEMBL1366933
CHEMBL2107339
DrugBank
DB06678
MedChem Express Bioactive Compound Library
HY-B0352A
NPC Screening Collection
TargetMol Bioactive Compound Library
T12632L
External IDs
27
Properties
(calculated by RDKit )
Molecular Weight
265.16
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
0
Rotatable Bonds
0
Ring Count
4
Aromatic Ring Count
2
cLogP
2.48
TPSA
19.37
Fraction CSP3
0.35
Chiral centers
1.0
Largest ring
7.0
QED
0.73
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
5-HT2
5-HT Receptor
Pathway
GPCR/G protein
Neuronal Signaling
Neuroscience
Source data