General
Preferred name
BUFURALOL
Synonyms
Bufuralol (hydrochloride) ()
Ro 3-4787 ()
Ro 3-4787 (hydrochloride) ()
Bufuralol hydrochloride ()
Bufuralol-d9 (hydrochloride) ()
P&D ID
PD008920
CAS
60398-91-6
59652-29-8
54340-62-4
64100-61-4
57704-15-1
64100-62-5
1173023-51-2
Tags
available
drug
Drug Status
investigational
approved
experimental
Max Phase
2.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Bufuralol (Ro 3-4787) hydrochloride is a potent non-selective, orally active ¦Â-adrenoreceptor antagonist with partial agonist activity. Bufuralol hydrochloride is a CYP2D6 probe substrate[1][2].
DESCRIPTION
Potent beta-adrenoceptor antagonist, which is metabolized by CYP2D6.
(GtoPdb)
DESCRIPTION
Bufuralol (Ro 3-4787) is a potent non-selective, orally active ¦Â-adrenoreceptor antagonist with partial agonist activity. Bufuralol hydrochloride is a CYP2D6 probe substrate[1][2][3][4].
PRICE
70
DESCRIPTION
Bufuralol (Ro 3-4787) is an orally active ??-adrenergic receptor blocker with a certain degree of sympathomimetic effects and can be used to study cardiovascular diseases.
DESCRIPTION
Bufuralol (Ro-34787) is a β-adrenoceptor blocker with partial peripheral vasodilating activity and is potentially useful for the treatment of hypertension. It is primarily metabolized by cytochrome P450 (CYP) isoform CYP2D6, with CYP1A2 and CYP2C19 also contributing to 1'-hydroxylation. Most beta blockers are aryloxypropanolamine-based, in this rare exception, the benzofuran oxygen is part of a ring instead of derived from the epichlorohydrin precursor.
(BOC Sciences Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
11
BOC Sciences Bioactive Compounds
ChEMBL Drugs
DrugBank
DrugCentral
DrugCentral Approved Drugs
DrugMatrix
Guide to Pharmacology
MedChem Express Bioactive Compound Library
NPC Screening Collection
ReFrame library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
47
Molecular Weight
261.17
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
2
Rotatable Bonds
4
Ring Count
2
Aromatic Ring Count
2
cLogP
3.42
TPSA
45.4
Fraction CSP3
0.5
Chiral centers
1.0
Largest ring
6.0
QED
0.89
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
GPCR/G protein
Neuronal Signaling
Solubility
Soluble in DMSO.
Target
Adrenergic Receptor
Source data
