General
Preferred name
AGMATINE
Synonyms
AGMATINE SULFATE ()
Agmatine sulfate salt ()
Agmatine (sulfate) ()
P&D ID
PD008916
CAS
2482-00-0
306-60-5
Tags
available
drug candidate
Drug indication
Discovery agent
Drug Status
experimental
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PRICE
29
DESCRIPTION
Agmatine is proposed as an endogenous ligand of I2 imidazoline binding sites with neurotransmitter-like action . It is synthesised in the brain from L-arginine and is an intermediate in polyamine biosynthesis . Agmatine is also produced as a metabolite by the human commensal microbe Bacteroides vulgatus.
(GtoPdb)
DESCRIPTION
Endogenous agonist at imidazoline receptors; may act as a neurotransmitter
(LOPAC library)
DESCRIPTION
Agmatine sulfate (Agmatine sulfate salt) is a bioactive metabolite of the arginine amino acid. It exerts modulatory action at multiple molecular targets, such as neurotransmitter systems, ion channels and nitric oxide synthesis. It is an endogenous agonist at imidazoline receptor and a NO synthase inhibitor.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
17
Cayman Chemical Bioactives
Concise Guide to Pharmacology 2017/18
Concise Guide to Pharmacology 2019/20
Concise Guide to Pharmacology 2021/22
Concise Guide to Pharmacology 2023/24
Drug Repurposing Hub
DrugBank
DrugMAP
DrugMatrix
Enamine BioReference Compounds
Guide to Pharmacology
Ki Database
LOPAC library
MedChem Express Bioactive Compound Library
ReFrame library
TargetMol Bioactive Compound Library
The Spectrum Collection
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
51
Molecular Weight
130.12
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
4
Rotatable Bonds
4
Ring Count
0
Aromatic Ring Count
0
cLogP
-0.79
TPSA
87.92
Fraction CSP3
0.8
Chiral centers
0.0
Largest ring
0.0
QED
0.23
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
Endogenous Metabolite
Imidazoline Receptor
NO Synthase
ADRA2C, ASIC3, CACNA1B, CHRNA1, GRIN1, KCNJ1, NISCH
MOA
nitric oxide synthase inhibitor
Pathway
Immunology/Inflammation
Metabolism
Neuroscience
Metabolic Enzyme/Protease
Neuronal Signaling
Source data
