General
Preferred name
PYRIDOXAL PHOSPHATE
Synonyms
Pyridoxal-p ()
PYRIDOXAL CALCIUM PHOSPHATE ()
Pyridoxal 5¡ä-phosphate ()
PLP ()
Codecarboxylase ()
Pyridoxyl phosphate ()
Pyridoxal 5??-phosphate ()
pyridoxal 5'-phosphate ()
PAL-P ()
Vitamin B6 phosphate ()
Pyridoxal 5'-phosphate hydrate ()
Pyridoxal 5??phosphate ()
Pyridoxal 5'-?phosphate (monohydrate) ()
Pyridoxal 5′-phosphate ()
Pyridoxal phosphate (monohydrate) ()
Pyridoxal 5-phosphate monohydrate ()
pyridoxal 5'-phosphate, PAL-P, PLP, Vitamin B6 phosphate ()
pyridoxal 5-phosphate ()
Pyridoxal phosphate hydrate ()
Pyridoxal 5-phosphate ()
NSC-82388 ()
Pyridoxal phosphate monohydrate ()
Pyridoxal 5'-phosphate (hydrate) ()
P&D ID
PD008883
CAS
853645-22-4
54-47-7
52064-48-9
41468-25-1
Tags
drug candidate
natural product
drug
available
Approved by
FDA
Drug Status
nutraceutical
investigational
approved
Drug indication
Malnutrition
Max Phase
Phase 3
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
MOA Pyridoxal Phosphate is a coenzyme of many enzymatic reactions. It is the active form of vitamin B6 which comprises three natural organic compounds, pyridoxal, pyridoxamine and pyridoxine. Pyridoxal phosphate acts as a coenzyme in all transamination reactions, and in some decarboxylation and deamination reactions of amino acids. The aldehyde group of pyridoxal phosphate forms a Schiff-base linkage with the epsilon-amino group of a specific lysine group of the aminotransferase enzyme. The alpha-amino group of the amino acid substrate displaces the epsilon-amino group of the active-site lysine residue. The resulting aldimine becomes deprotonated to become a quinoid intermediate, which in turn accepts a proton at a different position to become a ketimine. Ketimine becomes hydrolyzed so that the amino group remains on the protein complex.
Compound Sets
21
Cayman Chemical Bioactives
20352
ChEMBL Drugs
CHEMBL82202
CHEMBL3181870
CHEMBL3989490
Concise Guide to Pharmacology 2017/18
5249
Concise Guide to Pharmacology 2019/20
5249
Concise Guide to Pharmacology 2021/22
5249
Concise Guide to Pharmacology 2023/24
5249
Drug Repurposing Hub
DrugBank
DB00114
DrugBank Approved Drugs
DB00114
DrugCentral
3506
DrugCentral Approved Drugs
3506
DrugMAP
DMO2K0J
DrugMAP Approved Drugs
DMO2K0J
DrugMatrix
Guide to Pharmacology
5249
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL82202
MedChem Express Bioactive Compound Library
HY-B1744
HY-W011727A
NPC Screening Collection
ReFrame library
Selleckchem Bioactive Compound Library
pyridoxal-phosphate
pyridoxal-phosphate-monohydrate
TargetMol Bioactive Compound Library
T3578
T5085
External IDs
62
Properties
(calculated by RDKit )
Molecular Weight
247.02
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
3
Rotatable Bonds
4
Ring Count
1
Aromatic Ring Count
1
cLogP
0.52
TPSA
116.95
Fraction CSP3
0.25
Chiral centers
0.0
Largest ring
6.0
QED
0.52
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
Metabolism
AADAT, ABAT, AGXT, AGXT2, ALAS1, AZIN2, BCAT1, BCAT2, CBS, CCBL1, CCBL2, CSAD, CTH, DDC, FTCD, GAD1, GAD2, GADL1, GCAT, GLDC, GOT1, GOT2, GPT, GPT2, HDC, IGSF10, KYNU, MOCOS, NFS1, OAT, ODC1, PDXDC1, PDXP, PHYKPL, PNPO, PROSC, PSAT1, PYGB, PYGL, PYGM, SCLY, SDS, SDSL, SEPSECS, SGPL1, SHMT1, SHMT2, SPTLC1, SPTLC2, SPTLC3, SRR, TAT, THNSL1
Endogenous Metabolite
Reverse Transcriptase
Vitamin
Therapeutic Class
Dietary supplement
Pathway
Anti-infection
Metabolic Enzyme/Protease
Source data