General
Preferred name
CITRIC ACID
Synonyms
Citrate ()
Citro ()
Citretten ()
ANHYDROUS CITRIC ACID ()
citric-acid ()
SODIUM CITRATE ()
CITRIC ACID MONOHYDRATE ()
Citric acid hydrate ()
Citric acid,anhydrous ()
Citric acid component of phexxi ()
Citric acid,hydrous ()
Citric acid monoglyceride ()
NSC-112226 ()
Citric acid, hydrous ()
NSC-30279 ()
Citric acid component of clenpiq ()
E-330 ()
Citric acid bp ()
Urologic G ()
Citric acid component of prepopik ()
INS-330 ()
FEMA NO. 2306 ()
B1650 ()
NSC-626579 ()
Acidum citricum monohydrate ()
Acidum citricum ()
INS NO.330 ()
Citric acid component of renacidin ()
Citric acid anhydrous ()
E330 ()
Aciletten ()
Citricum acidum ()
Citric acid, anhydrous ()
P&D ID
PD008874
CAS
126-44-3
12262-73-6
77-92-9
5949-29-1
Tags
available
drug candidate
drug
Approved by
FDA
First approval
1982
Drug indication
Discovery agent
Acute kidney injury
Renal insufficiency
Drug Status
vet_approved
approved
nutraceutical
Max Phase
4.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Citric acid is a natural preservative and food tartness enhancer. Citric acid induces apoptosis and cell cycle arrest at G2/M phase and S phase in HaCaT cells. Citric acid cause oxidative damage of the liver by means of the decrease of antioxidative enzyme activities. Citric acid causes renal toxicity in mice[1][2][3].
PRICE 29
PRICE 29
DESCRIPTION 1. Citric acid (Citro) (1-2 g/kg) can decrease brain lipid peroxidation and inflammation, liver damage, and DNA fragmentation. 2. Citric acid denture cleansers can reduce C. albicans biofilm accumulation and cell viability. However, this CT did not prevent biofilm recolonization. (TargetMol Bioactive Compound Library)
DESCRIPTION Citric Acid Monohydrate is a tricarboxylic acid found in citrus fruits. Citric acid is used as an excipient in pharmaceutical preparations due to its antioxidant properties. It maintains stability of active ingredients and is used as a preservative. (TargetMol Bioactive Compound Library)
Cell lines
1
Organisms
0
Compound Sets
25
ChEMBL Approved Drugs
CHEMBL1261
ChEMBL Drugs
CHEMBL1261
CHEMBL2107737
Concise Guide to Pharmacology 2017/18
2478
Concise Guide to Pharmacology 2019/20
2478
Concise Guide to Pharmacology 2021/22
2478
Concise Guide to Pharmacology 2023/24
2478
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugBank
DB04272
DrugBank Approved Drugs
DB04272
DrugCentral
666
DrugCentral Approved Drugs
666
DrugMAP
DM37NYK
DM80YI7
DrugMatrix
Guide to Pharmacology
2478
JUMP-Target 1 Compound Set
19782904
MedChem Express Bioactive Compound Library
HY-N1428
NCATS Inxight Approved Drugs
XF417D3PSL
NPC Screening Collection
Other bioactive compounds
ReFrame library
Selleckchem Bioactive Compound Library
citric-acid
citric-acid-monohydrate
TargetMol Bioactive Compound Library
T5S0636
T5669
The Spectrum Collection
ZINC Tool Compounds
ZINC000000895081
External IDs
79
Properties
(calculated by RDKit )
Molecular Weight
192.03
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
4
Rotatable Bonds
5
Ring Count
0
Aromatic Ring Count
0
cLogP
-1.25
TPSA
132.13
Fraction CSP3
0.5
Chiral centers
0.0
Largest ring
0.0
QED
0.43
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
antibiotic
Apoptosis
Bacterial
Endogenous Metabolite
AKR1B1, ANG, APRT, BHMT, C8G, CA4, CPB1, CS, CTDSP1, GNMT, HGS, HS3ST3A1, IL4I1, ITPA, LSM6, MDH2, MIF, PDE5A, PKD2L1, PLEKHA1, RNASE1, RNASE3, SRC, TNFSF13B, UCK2
RNASE1
MOA
coagulation factor inhibitor
Pathway
Metabolism
Microbiology/virology
Anti-infection
Metabolic Enzyme/Protease
Source data