General
Preferred name
FENFLURAMINE
Synonyms
d-Fenfluramine ()
DEXFENFLURAMINE ()
l-Fenfluramine ()
Fenfluramine (-) ()
Fenfluramine (+) ()
FENFLURAMINE HYDROCHLORIDE ()
3-trifluoromethyl-N-Ethylamphetamine (hydrochloride) ()
Ponderax pa ()
Fenfluramin ()
Brabafen ()
Pesos ()
Z-008 ()
Obedrex ()
ZX008 ()
Fenfluramina ()
ZX-008 ()
Phenfluramine ()
J5.760F ()
Rotondin ()
S-768 ()
Z008 ()
Acino ()
AHR-3002 ()
Fintepla ()
HHR-965 ()
Ponderax ()
Ponderax Pacaps ()
Fenfluramine hcl ()
Ganal ()
Dl-fenfluramine hydrochloride ()
P&D ID
PD008865
CAS
5220-89-3
458-24-2
404-82-0
16105-77-4
Tags
available
drug
Approved by
EMA
PMDA
FDA
First approval
1963
2020
Drug indication
photosensitive epilepsy
Obesity
Epilepsy
Dravet syndrome
LennoxGastaut syndrome
Drug Status
approved
withdrawn
investigational
illicit
Max Phase
4.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION The approved drug was called dexfenfluramine. It withdrawn from use as a weight-loss aid due to adverse cardiac events . Fenfluramine has subsequently been re-introduced as an anti-seizure medication for rare forms of pediatric intractable epilepsy. (GtoPdb)
Compound Sets
20
Axon Medchem Screening Library
2850
Cayman Chemical Bioactives
22491
ChEMBL Approved Drugs
CHEMBL87493
CHEMBL2106217
ChEMBL Drugs
CHEMBL87493
CHEMBL2106217
Concise Guide to Pharmacology 2017/18
4613
Concise Guide to Pharmacology 2019/20
4613
Concise Guide to Pharmacology 2021/22
4613
Concise Guide to Pharmacology 2023/24
4613
DrugBank
DB00574
DrugBank Approved Drugs
DB00574
DrugCentral
1150
DrugCentral Approved Drugs
1150
DrugMAP
DM0762O
DrugMatrix
Guide to Pharmacology
4613
Ki Database
d-Fenfluramine
Fenfluramine
Fenfluramine (+)
Fenfluramine (-)
l-Fenfluramine
NCATS Inxight Approved Drugs
3KC089243P
Novartis Chemogenetic Library (NIBR MoA Box)
NPC Screening Collection
Withdrawn 2.0
DB00574
External IDs
48
Properties
(calculated by RDKit )
Molecular Weight
231.12
Hydrogen Bond Acceptors
1
Hydrogen Bond Donors
1
Rotatable Bonds
4
Ring Count
1
Aromatic Ring Count
1
cLogP
3.25
TPSA
12.03
Fraction CSP3
0.5
Chiral centers
1.0
Largest ring
6.0
QED
0.84
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Member status
virtual
MOA
HTR2B gene stimulator
ATC
A08AA02
N03AX26
Toxicity type
NULL
Target
5-HT releasing agent
Source data