General
Preferred name
BUFOTENINE
Synonyms
5-HT,N,N-DIMETHYL ()
DMT,5-OH ()
5-hydroxy DMT (hydrochloride) ()
5-hydroxy DMT (hydrochloride) (exempt preparation) ()
P&D ID
PD008859
CAS
487-93-4
55206-22-9
Tags
drug candidate
natural product
available
Drug indication
Discovery agent
Drug Status
experimental
illicit
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Bufotenin is a serotonin-like bioactive toxin found in the skin of certain poisonous toads, mushrooms and tree seeds that has hallucinogenic effects.
(GtoPdb)
METABOLISM
Upon oral administration, bufotenine is extensively metabolized by monoamine oxidase enzymes.
TOXICITY
Ingestion of Bufo toad venom and eggs by humans has resulted in several reported cases of poisoning, some of which resulted in death. The acute toxicity of bufotenin in rodents has been calculated to have an LD50 of between 200 and 300 mg/kg, which by comparison, is comparable to the LD50 for intravenous morphine (200-300 mg/kg) in mice. Respiratory arrest may occur, possibly leading to death.
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
0
Organisms
1
Compound Sets
6
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
33
Molecular Weight
204.13
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
2
Rotatable Bonds
3
Ring Count
2
Aromatic Ring Count
2
cLogP
1.98
TPSA
39.26
Fraction CSP3
0.33
Chiral centers
0.0
Largest ring
6.0
QED
0.8
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Source data
