General
Preferred name
CHLORPHENTERMINE
Synonyms
CHLORPHENTERMINE HYDROCHLORIDE ()
Pre-Sate ()
W 2426 ()
W-2426 ()
NSC-76098 ()
Chlorphentermine hcl ()
S-62 ()
P&D ID
PD008784
CAS
461-78-9
151-06-4
Tags
available
drug
Approved by
FDA
Drug indication
Anorexic
Appetite suppressant
Drug Status
illicit
approved
withdrawn
Max Phase
Phase 4
First approval
1982
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PHARMACODYNAMICS
Chlorphentermine is a relatively weak stimulant with little abuse potential. It presents a prominent serotonergic profile leading to pulmonary hypertension and cardiac fibrosis after prolonged use. Thus, this drug is no longer used.
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
11
ChEMBL Approved Drugs
ChEMBL Drugs
DrugBank
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
Ki Database
NPC Screening Collection
ReFrame library
Withdrawn 2.0
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
33
Properties
(calculated by RDKit )
Molecular Weight
183.08
Hydrogen Bond Acceptors
1
Hydrogen Bond Donors
1
Rotatable Bonds
2
Ring Count
1
Aromatic Ring Count
1
cLogP
2.62
TPSA
26.02
Fraction CSP3
0.4
Chiral centers
0.0
Largest ring
6.0
QED
0.75
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
ATC
A08AA
Toxicity type
cardiovascular
Source data