General
Preferred name
(±)-Huperzine A
Synonyms
(¡À)-Huperzine A ()
(??)-Huperzine A ()
P&D ID
PD008704
CAS
120786-18-7
Tags
natural product
available
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Huperzine A exhibited protective effects against d-gal-induced hepatotoxicity and inflamm-aging by inhibiting AChE activity and via the activation of the cholinergic anti-inflammatory pathway. The huperzine A mechanism might be involved in the inhibition of DAMPs-mediated NF-κB nuclear localization and activation. Huperzine A is a potential therapeutic agent for Alzheimer's disease. (BOC Sciences Bioactive Compounds)
Compound Sets
3
BOC Sciences Bioactive Compounds
huperzine-a-cas-120786-18-7-360073
EU-OPENSCREEN Bioactive Compound Library
EOS100152
MedChem Express Bioactive Compound Library
HY-17388
External IDs
15
Properties
(calculated by RDKit )
Molecular Weight
242.14
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
2
Rotatable Bonds
0
Ring Count
3
Aromatic Ring Count
1
cLogP
2.0
TPSA
58.88
Fraction CSP3
0.4
Chiral centers
2.0
Largest ring
6.0
QED
0.68
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
Neuronal Signaling
Target
Cholinesterase (ChE)
Source data