General
Preferred name
ELACRIDAR
Synonyms
GW0918 ()
GW120918 ()
GF120918 ()
GG918 ()
ELACRIDAR HYDROCHLORIDE ()
Elacridar (hydrochloride) ()
GF120918A ()
GW120918, GG918, GW0918 ()
Elacridar (GF120918) ()
LY335979 ()
LY-335979 ()
GF 120918 ()
GF-120918A ()
GF 120918A ()
Elacridar hcl ()
P&D ID
PD008694
CAS
143851-98-3
143664-11-3
178436-75-4
Tags
available
drug candidate
Drug indication
Solid tumour/cancer
Drug Status
investigational
Max Phase
2.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Elacridar (GF120918) is a dual inhibitor of P-glycoprotein (ABCB1; MDR protein 1) and breast cancer resistance protein (BCRP; ABCG2) . These proteins are efflux transporters that are associated with resistance to chemotherapeutic drugs in tumours. Elacridar is a third-generation allosteric (non-competitive) ABCB1 inhibitor.
(GtoPdb)
PRICE
61
DESCRIPTION
Elacridar hydrochloride (GF120918A) is an orally active P-glycoprotein (P-gp) and breast cancer resistance protein (BCRP) inhibitor. Elacridar hydrochloride can be used to examine the influence of efflux transporters on agent distribution to brain and it can be used for the research of cancer[1][2].
DESCRIPTION
Elacridar (GG918) is a potent inhibitor of P-glycoprotein and BCRP.
(TargetMol Bioactive Compound Library)
DESCRIPTION
Potent and selective KCC2 inhibitor
(Tocris Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
2
Organisms
0
Compound Sets
14
Axon Medchem Screening Library
Cayman Chemical Bioactives
ChEMBL Drugs
Drug Repurposing Hub
DrugBank
DrugMAP
DrugMatrix
Guide to Pharmacology
ReFrame library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
Tocris Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
51
Molecular Weight
563.24
Hydrogen Bond Acceptors
6
Hydrogen Bond Donors
2
Rotatable Bonds
8
Ring Count
6
Aromatic Ring Count
5
cLogP
5.56
TPSA
92.89
Fraction CSP3
0.24
Chiral centers
0.0
Largest ring
6.0
QED
0.24
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
BCRP
P-gp (P-glycoprotein)
ABCB1
P-gp inhibitor
P-glycoprotein
P-gp
Primary Target
Multidrug Transporters
MOA
Inhibitor
P glycoprotein inhibitor
Pathway
Membrane Transporter/Ion Channel
Neuroscience
Source data
