General
Preferred name
dapoxetine
Synonyms
DAPOXETINE HYDROCHLORIDE ()
LY-210448 hydrochloride ()
LY-210448 ()
Priligy ()
Dapoxetine HCl ()
Dapoxetine (hydrochloride) ()
Dapoxetine (as hydrochloride) ()
LY210448 HCL ()
Kutub ()
P&D ID
PD008691
CAS
129938-20-1
119356-77-3
Tags
natural product
drug
available
Drug indication
Premature ejaculation
Antidepressant
Drug Status
investigational
approved
Max Phase
Phase 4
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Dapoxetine hydrochloride (PubChem CID 71352) is the component used in marketed formulations.
(GtoPdb)
DESCRIPTION
Macrolide antibiotic
(Tocris Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
21
AdooQ Bioactive Compound Library
Cayman Chemical Bioactives
ChEMBL Approved Drugs
ChEMBL Drugs
Concise Guide to Pharmacology 2017/18
Concise Guide to Pharmacology 2019/20
Concise Guide to Pharmacology 2021/22
Concise Guide to Pharmacology 2023/24
Drug Repurposing Hub
DrugBank
DrugCentral
DrugCentral Approved Drugs
DrugMAP
EU-OPENSCREEN Bioactive Compound Library
Guide to Pharmacology
MedChem Express Bioactive Compound Library
ReFrame library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
The Spectrum Collection
Tocris Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
43
Molecular Weight
305.18
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
0
Rotatable Bonds
6
Ring Count
3
Aromatic Ring Count
3
cLogP
4.91
TPSA
12.47
Fraction CSP3
0.24
Chiral centers
1.0
Largest ring
6.0
QED
0.64
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
GPCR/G protein
Neuroscience
Neuronal Signaling
Target
5-HT
HTR1A, HTR1B, HTR2C, SLC6A4
Serotonin Transporter
5-HT Receptor,Serotonin Transporter
Primary Target
5-HT Transporters
MOA
Inhibitor
selective serotonin reuptake inhibitor (SSRI)
Indication
premature ejaculation (PE)
Source data
