General
Preferred name
BICIFADINE
Synonyms
BICIFADINE HYDROCHLORIDE ()
CL-220075 ()
Bicifadine hcl ()
CL 220,075 ()
P&D ID
PD008686
CAS
66504-75-4
71195-57-8
Tags
available
drug candidate
Drug indication
Analgesic
Neuropathic pain
Chronic low back pain
Drug Status
investigational
Max Phase
Phase 3
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Noradrenalin, 5-HT and dopamine re-uptake inhibitor
(Tocriscreen Plus)
DESCRIPTION
Selective serotonin reuptake inhibitor (SSRI)
(Tocris Bioactive Compound Library)
DESCRIPTION
Bicifadine hydrochloride is a potent antagonist of SLC6A2 (noradrenalin transporter) (IC50 = 55 nM). Bicifadine also has antagonistic activity at the 5-HT receptors and dopamine transporters (IC50 = 117 nM and 910 nM, respectively). It exhibits antinociceptive and antiallodynic properties in rodent models of acute, persistent, and chronic pain.
(BOC Sciences Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
9
BOC Sciences Bioactive Compounds
ChEMBL Drugs
DrugBank
DrugMAP
DrugMatrix
Novartis Chemogenetic Library (NIBR MoA Box)
ReFrame library
Tocris Bioactive Compound Library
Tocriscreen Plus
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
29
Properties
(calculated by RDKit )
Molecular Weight
173.12
Hydrogen Bond Acceptors
1
Hydrogen Bond Donors
1
Rotatable Bonds
1
Ring Count
3
Aromatic Ring Count
1
cLogP
1.86
TPSA
12.03
Fraction CSP3
0.5
Chiral centers
2.0
Largest ring
6.0
QED
0.68
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Target Type
Transporters
Primary Target
Adrenergic Transporters
MOA
Inhibitor
NMDA Antagonists
Norepinephrine Transporter (NET) Inhibitors
Serotonin Transporter (SERT) Inhibitors
Member status
member
Therapeutic Class
Analgesics
Source data