General
Preferred name
BICIFADINE
Synonyms
BICIFADINE HYDROCHLORIDE ()
CL 220,075 ()
CL-220075 ()
Bicifadine hcl ()
Bicifadina ()
P&D ID
PD008686
CAS
66504-75-4
71195-57-8
Tags
available
drug candidate
Drug indication
Chronic low back pain
Neuropathic pain
Diabetic neuropathy
Drug Status
investigational
Max Phase
3.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Selective serotonin reuptake inhibitor (SSRI) (Tocris Bioactive Compound Library)
DESCRIPTION Noradrenalin, 5-HT and dopamine re-uptake inhibitor (Tocriscreen Plus)
DESCRIPTION Bicifadine hydrochloride is a potent antagonist of SLC6A2 (noradrenalin transporter) (IC50 = 55 nM). Bicifadine also has antagonistic activity at the 5-HT receptors and dopamine transporters (IC50 = 117 nM and 910 nM, respectively). It exhibits antinociceptive and antiallodynic properties in rodent models of acute, persistent, and chronic pain. (BOC Sciences Bioactive Compounds)
DESCRIPTION Bicifadine hydrochloride is a potent antagonist of SLC6A2 (noradrenalin transporter) (IC50 = 54.7 nM). Bicifadine also has antagonistic activity at the 5-HT receptors and dopamine transporters (IC50 = 117 nM and 910 nM, respectively). It exhibits antinociceptive and antiallodynic properties in rodent models of acute, persistent, and chronic pain. (Enamine Bioactive Compounds)
Compound Sets
10
BOC Sciences Bioactive Compounds
bicifadine-hydrochloride-cas-66504-75-4-item-40765
ChEMBL Drugs
CHEMBL544862
CHEMBL511099
DrugBank
DB04889
DrugMAP
DM42GP9
DrugMatrix
Enamine Bioactive Compounds
EBC-245045
Novartis Chemogenetic Library (NIBR MoA Box)
ReFrame library
Tocris Bioactive Compound Library
4357
Tocriscreen Plus
4357
External IDs
31
Properties
(calculated by RDKit )
Molecular Weight
173.12
Hydrogen Bond Acceptors
1
Hydrogen Bond Donors
1
Rotatable Bonds
1
Ring Count
3
Aromatic Ring Count
1
cLogP
1.86
TPSA
12.03
Fraction CSP3
0.5
Chiral centers
2.0
Largest ring
6.0
QED
0.68
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target Type
Transporters
Primary Target
Adrenergic Transporters
MOA
Inhibitor
NMDA Antagonists
Norepinephrine Transporter (NET) Inhibitors
Serotonin Transporter (SERT) Inhibitors
Member status
member
Therapeutic Class
Analgesics
Source data