General
Preferred name
acadesine
Synonyms
AICAR ()
NSC105823 ()
AICA Riboside ()
AICAR (Acadesine) ()
AICAR (phosphate) ()
Acadesine phosphate ()
AICA Riboside phosphate ()
NSC105823, AICA Riboside ()
NSC-105823 ()
GP-1-110 ()
Acadesina ()
P&D ID
PD008673
CAS
2627-69-2
681006-28-0
Tags
available
drug
Drug indication
Diabetic complication
Cardiovascular disease
Drug Status
approved
investigational
Max Phase
3.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PRICE
29
DESCRIPTION
AICAR phosphate (Acadesine phosphate) is an adenosine analog and a AMPK activator. AICAR phosphate regulates the glucose and lipid metabolism, and inhibits proinflammatory cytokines and iNOS production. AICAR phosphate is also an autophagy, YAP and mitophagy inhibitor[1][2].
DESCRIPTION
PDE inhibitor (non-selective)
(Tocris Bioactive Compound Library)
DESCRIPTION
AMPK activator
(Tocriscreen Plus)
DESCRIPTION
AICAR (Acadesine) is an AMPK activator that causes ZMP accumulation, thereby mimicking the stimulatory effect of AMP on both AMPK and AMPKK. It is commonly used in research related to diabetes, cardiovascular diseases, and tumors.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
17
AdooQ Bioactive Compound Library
Cayman Chemical Bioactives
ChEMBL Drugs
Drug Repurposing Hub
DrugBank
DrugCentral
DrugCentral Approved Drugs
DrugMAP
Guide to Pharmacology
MedChem Express Bioactive Compound Library
Novartis Chemogenetic Library (NIBR MoA Box)
NPC Screening Collection
ReFrame library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
Tocris Bioactive Compound Library
Tocriscreen Plus
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
49
Molecular Weight
258.1
Hydrogen Bond Acceptors
8
Hydrogen Bond Donors
5
Rotatable Bonds
3
Ring Count
2
Aromatic Ring Count
1
cLogP
-2.82
TPSA
156.85
Fraction CSP3
0.56
Chiral centers
4.0
Largest ring
5.0
QED
0.39
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target Type
Enzymes
Pathway
Autophagy
Chromatin/Epigenetic
PI3K/Akt/mTOR signaling
Stem Cells
Epigenetics
Metabolic Enzyme/Protease
PI3K/Akt/mTOR
Stem Cell/Wnt
Primary Target
AMPK
MOA
Activator
"AMP activated protein kinase stimulator
AMPK Activator"
AMP activated protein kinase stimulator
AMPK activator
Member status
virtual
Target
Endogenous Metabolite
Mitophagy
YAP
AMPK,Mitophagy
Source data
