General
Preferred name
AMONAFIDE
Synonyms
AS1413 ()
NSC308847 ()
Quinamed ()
Nafidimide ()
Amonafide (AS1413) ()
amonafide dihydrochloride ()
NSC308847,AS1413 ()
AMONAFIDE L-MALATE ()
NSC-308847 ()
Amonafida ()
AS-1413 ()
Xanafide ()
XAN 02 ()
XAN-02 ()
AS 1413 ()
Amonafide malate ()
P&D ID
PD008660
CAS
69408-81-7
618863-60-8
Tags
available
drug candidate
nuisance
Drug Status
investigational
Max Phase
3.0
Drug indication
Acute myeloid leukemia
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Amonafide is a topoisomerase II inhibitor and DNA intercalator that induces apoptotic signaling by blocking the binding of Topo II to DNA.
PRICE
75
DESCRIPTION
Amonafide (NSC-308847,AS1413)(AS1413) produces protein-associated DNA-strand breaks through a topoisomerase II-mediated reaction, but does not produce topoisomerase I-mediated DNA cleavage.
(TargetMol Bioactive Compound Library)
DESCRIPTION
Amonafide L-malate is the malate salt of amonafide, an imide derivative of naphthalic acid, with potential antineoplastic activity. Amonafide intercalates into DNA and inhibits topoisomerase II, resulting in DNA double-strand breaks (DSB) and inhibition of DNA replication and RNA synthesis.
(BOC Sciences Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
43
Organisms
0
Compound Sets
13
AdooQ Bioactive Compound Library
BOC Sciences Bioactive Compounds
Cayman Chemical Bioactives
ChEMBL Drugs
Drug Repurposing Hub
DrugBank
DrugMatrix
MedChem Express Bioactive Compound Library
NIH Mechanistic Set
Nuisance compounds in cellular assays
ReFrame library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
43
Molecular Weight
283.13
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
1
Rotatable Bonds
3
Ring Count
3
Aromatic Ring Count
2
cLogP
1.58
TPSA
66.64
Fraction CSP3
0.25
Chiral centers
0.0
Largest ring
6.0
QED
0.69
Structural alerts
1
Intercalation
Nuisance compounds
Related compounds
Custom attributes
(extracted from source data)
Target
Topo II
Topoisomerase
TOP2A, TOP2B
MOA
Topoisomerase inhibitor
Pathway
Cell Cycle/DNA Damage
DNA Damage/DNA Repair
Source data
