General
Preferred name
Lobeline
Synonyms
alpha-Lobeline hydrochloride ()
LOBELINE HYDROCHLORIDE ()
¦Á-Lobeline hydrochloride ()
α-Lobeline hydrochloride ()
L-Lobeline hydrochloride ()
Lobeline alpha (-) hydrochoride ()
¦Á-Lobeline (hydrochloride) ()
Lobeline (hydrochloride) ()
α-Lobeline (hydrochloride) ()
L-Lobeline (hydrochloride) ()
Lobeline sulfate ()
.alpha.-lobeline ()
Alpha-Lobeline ()
(-)-Lobeline ()
Inflatine ()
Lobelina ()
Lobelinum ()
NSC-757421 ()
(–)-Lobelin (hydrochloride) ()
P&D ID
PD008645
CAS
90-69-7
134-64-5
134-63-4
Tags
available
drug candidate
natural product
Drug indication
Attention deficit hyperactivity disorder
Substance use disorder
Drug Status
investigational
Max Phase
2.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PRICE
29
DESCRIPTION
Lobeline hydrochloride (??-Lobeline hydrochloride) is a nicotinic receptor agonist, acting as an effective antagonist at both ??4??2 and ??3??2 neuronal nicotinic receptor subtypes.
DESCRIPTION
Lobeline is a phytochemical from Lobelia species. It has been proposed to offer therapeutic benefit in a range of human disease states. At the molecular level lobeline has been reported as a nicotinic acetylcholine receptor agonist .
(GtoPdb)
DESCRIPTION
Neuronal nicotinic acetylcholine receptor agonist
(LOPAC library)
DESCRIPTION
Nicotinic agonist
(Tocriscreen Total)
DESCRIPTION
Lobeline hydrochloride (α-Lobeline hydrochloride) is a nicotinic receptor agonist, acting as an effective antagonist at both α4β2 and α3β2 neuronal nicotinic receptor subtypes.
(TargetMol Bioactive Compound Library)
DESCRIPTION
Lobelin sulphate is a pyridine alkaloid found in many plants and acts as a nicotinic cholinergic receptor antagonist.
(BOC Sciences Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
0
Organisms
2
Compound Sets
17
BOC Sciences Bioactive Compounds
Cayman Chemical Bioactives
ChEMBL Drugs
Drug Repurposing Hub
DrugBank
DrugMAP
EU-OPENSCREEN Bioactive Compound Library
EUbOPEN Chemogenomics Library
Guide to Pharmacology
LOPAC library
MedChem Express Bioactive Compound Library
NIH Clinical Collections (NCC)
Novartis Chemogenetic Library (NIBR MoA Box)
Other bioactive compounds
ReFrame library
TargetMol Bioactive Compound Library
Tocriscreen Total
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
63
Molecular Weight
337.2
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
1
Rotatable Bonds
6
Ring Count
3
Aromatic Ring Count
2
cLogP
4.24
TPSA
40.54
Fraction CSP3
0.41
Chiral centers
3.0
Largest ring
6.0
QED
0.8
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Selectivity
Nicotinic
Target
nAChR
Nicotinic Receptor
CHRNA10, CHRNA9, SLC18A2
Dopamine Transporter
MOA
AChR antagonist
Dopamine Receptor Modulators
alpha4beta2 nicotinic acid receptor partial agonist
acetylcholine receptor antagonist
Member status
member
Indication
smoking cessation
Pathway
Neuroscience
Membrane Transporter/Ion Channel
Neuronal Signaling
Recommended Cell Concentration
None
Source data
