General
Preferred name
TARENFLURBIL
Synonyms
Flurizan ()
MPC7869 ()
(R)-Flurbiprofen ()
R-flurbiprofen ()
Flurbiprofen (Ansaid) ()
(R)-flurbiprofen ()
E-7869 ()
MPC-7869 ()
Flurbiprofen, (r)- ()
Tarenflurbilo ()
P&D ID
PD008630
CAS
51543-40-9
5104-49-4
Tags
available
drug candidate
Drug Status
investigational
Max Phase
3.0
Drug indication
Dementia
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Tarenflurbil or R-flurbiprofen, is the single enantiomer of the racemate NSAID . Research and trials for Alzheimer's disease were conducted by Myriad Genetics but the company discontinued development in 2008. This compound is the archetypal γ-secretase modulator (GSM) that blocks γ-secretase cleavage of amyloid-β protein precursor (AβPP) to generate the longer, 42-residue amyloid-β (Aβ42) without changing the production of total Aβ (e.g. CHF5074) . (GtoPdb)
DESCRIPTION Tarenflurbil ((R)-Flurbiprofen) is the R-enantiomer of the racemate NSAID Flurbiprofen, Tarenflurbil ((R)-Flurbiprofen) inhibits the binding of [3H]9-cis-RA to RXR¦Á LBD with IC50 of 75 ¦ÌM. Tarenflurbil can be used for Alzheimer's disease research.
PRICE 29
DESCRIPTION gamma-secretase inhibitor; lowers Abeta42 levels in vitro (Tocriscreen Plus)
DESCRIPTION Tarenflurbil ((R)-Flurbiprofen) is the non-cyclooxygenase inhibiting R-enantiomer of the NSAID flurbiprofen, evaluated as a treatment for Alzheimer's disease. (TargetMol Bioactive Compound Library)
Compound Sets
12
AdooQ Bioactive Compound Library
A12433
Cayman Chemical Bioactives
70255
ChEMBL Drugs
CHEMBL190083
Drug Repurposing Hub
DrugBank
DB05289
DrugMAP
DMFIVSR
Guide to Pharmacology
7340
MedChem Express Bioactive Compound Library
HY-10291
Novartis Chemogenetic Library (NIBR MoA Box)
ReFrame library
TargetMol Bioactive Compound Library
T5843
Tocriscreen Plus
4495
External IDs
33
Properties
(calculated by RDKit )
Molecular Weight
244.09
Hydrogen Bond Acceptors
1
Hydrogen Bond Donors
1
Rotatable Bonds
3
Ring Count
2
Aromatic Ring Count
2
cLogP
3.68
TPSA
37.3
Fraction CSP3
0.13
Chiral centers
1.0
Largest ring
6.0
QED
0.89
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target Type
Enzymes
Member status
member
MOA
gamma-Secretase Inhibitors
NF-kappaB (NFKB) Modulators
Antiamyloidogenic Agents
gamma secretase inhibitor
cyclooxygenase inhibitor
Target
APH1B, BACE1, IKBKG, PSEN1, PSEN2, PTGS1, PTGS2
RAR/RXR
RXRα
Indication
rheumatoid arthritis, osteoarthritis
Pathway
Autophagy
Metabolism
Metabolic Enzyme/Protease
Vitamin D Related/Nuclear Receptor
Source data