General
Preferred name
PIMAVANSERIN
Synonyms
ACP-103 tartrate ()
ACP-103 ()
Nuplazid ()
PIMAVANSERIN TARTRATE ()
ACP 103 ()
P&D ID
PD008625
CAS
706782-28-7
706779-91-1
868855-07-6
Tags
available
drug candidate
drug
Approved by
FDA
First approval
2016
Drug Status
investigational
approved
Drug indication
Alzheimer disease
Parkinson disease
Max Phase
Phase 4
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Pimavanserin is an inverse agonist of the serotonin 5-HT2A receptor . Pharmaceutical formulations contain pimavanserin tartrate (PubChem CID 67017013) . (GtoPdb)
Compound Sets
23
AdooQ Bioactive Compound Library
A14434
Cayman Chemical Bioactives
23462
ChEMBL Approved Drugs
CHEMBL2111101
CHEMBL2448613
ChEMBL Drugs
CHEMBL2111101
CHEMBL2448613
Concise Guide to Pharmacology 2017/18
8423
Concise Guide to Pharmacology 2019/20
8423
Concise Guide to Pharmacology 2021/22
8423
Concise Guide to Pharmacology 2023/24
8423
Drug Repurposing Hub
DrugBank
DB05316
DrugBank Approved Drugs
DB05316
DrugCentral
5142
DrugCentral Approved Drugs
5142
DrugMAP
DMR7IVC
DMOJA5G
DrugMAP Approved Drugs
DMR7IVC
Guide to Pharmacology
8423
MedChem Express Bioactive Compound Library
HY-14557
NCATS Inxight Approved Drugs
JZ963P0DIK
Novartis Chemogenetic Library (NIBR MoA Box)
Other bioactive compounds
ReFrame library
Selleckchem Bioactive Compound Library
pimavanserin
TargetMol Bioactive Compound Library
T2076
T6946
External IDs
53
Properties
(calculated by RDKit )
Molecular Weight
427.26
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
1
Rotatable Bonds
8
Ring Count
3
Aromatic Ring Count
2
cLogP
4.67
TPSA
44.81
Fraction CSP3
0.48
Chiral centers
0.0
Largest ring
6.0
QED
0.67
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
GPCR/G protein
Neuroscience
Neuronal Signaling
Target
5-HT2A
DRD2, HTR2A
5-HT Receptor
MOA
5-HT Receptor inhibitor
SELECTIVE inverse agonist on the serotonin receptor subtype 5-HT2A
HTR2A (5HT2A) inverse agonist
"SELECTIVE inverse agonist on the serotonin receptor subtype 5-HT2A
HTR2A (5HT2A) inverse agonist"
serotonin receptor inverse agonist
Member status
virtual
Indication
Parkinson's Disease
Source data