General
Preferred name
Cardarine
Synonyms
GW501516 ()
CHEMBL38943 ()
GSK-516 ()
GW 1516 ()
Endurobol ()
GW 501516 ()
GW1516 ()
GW-501516 ()
GW-1516 ()
P&D ID
PD008609
CAS
317318-70-0
Tags
available
probe
drug candidate
Drug indication
Type-1 diabetes
Disorder of lipid metabolism
Drug Status
investigational
Max Phase
2.0
Probe info
Probe type
P&D approved
calculated probe
Probe selectivity
protein-selective
Probe sources
High-quality chemical probes
Probe Miner (suitable probes)
Tool Compound Set
Probe targets
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION GW 501516 (GW 1516) is a PPAR¦Ä agonist with an EC50 of 1.1 nM[1].
PRICE 61
DESCRIPTION GW 501516 (Endurobol) is a effective and highly specifc PPAR??/?? agonist (EC50: 1 nM), with 1000-fold selectivity over hPPAR??/??.
DESCRIPTION Potent LXR antagonist (Tocris Bioactive Compound Library)
DESCRIPTION GW 501516 (Endurobol) is a effective and highly specifc PPARβ/δ agonist (EC50: 1 nM), with 1000-fold selectivity over hPPARα/γ. (TargetMol Bioactive Compound Library)
Cell lines
1
Organisms
0
Compound Sets
24
AdooQ Bioactive Compound Library
A11437
Cayman Chemical Bioactives
10004272
36516
ChEMBL Drugs
CHEMBL38943
Concise Guide to Pharmacology 2017/18
2687
Concise Guide to Pharmacology 2019/20
2687
Concise Guide to Pharmacology 2021/22
2687
Concise Guide to Pharmacology 2023/24
2687
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugBank
DB05416
DrugMAP
DMPL2KM
EUbOPEN Chemogenomics Library
EUB0001148
Guide to Pharmacology
2687
High-quality chemical probes
PD008609
LINCS compound set
10417-101
MedChem Express Bioactive Compound Library
HY-10838
Novartis Chemogenetic Library (NIBR MoA Box)
NURSA ligand set
nursa/index.jsf?doi=10.1621%2F9IM9FSAA2B
Probe Miner (suitable probes)
Q03181/235200
ReFrame library
TargetMol Bioactive Compound Library
T6151
Tocris Bioactive Compound Library
5674
Tool Compound Set
ZINC Tool Compounds
ZINC000001549989
External IDs
28
Properties
(calculated by RDKit )
Molecular Weight
453.07
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
1
Rotatable Bonds
7
Ring Count
3
Aromatic Ring Count
3
cLogP
6.2
TPSA
59.42
Fraction CSP3
0.24
Chiral centers
0.0
Largest ring
6.0
QED
0.43
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
Peroxisome proliferator-activated receptor delta
PPARA, PPARD
PPAR
PPARδ
Pathway
Autophagy
DNA Damage/DNA Repair
Metabolism
Cell Cycle/DNA Damage
Metabolic Enzyme/Protease
Vitamin D Related/Nuclear Receptor
Primary Target
PPAR?
MOA
Agonist
Insulin Sensitizers
PPARdelta Agonists
PPAR receptor agonist
Member status
virtual
Recommended Cell Concentration
1 uM
Source data