General
Preferred name
GOLOTIMOD
Synonyms
Gamma-D-glutamyl-L-tryptophan ()
SCV 07 ()
Golotimod (hydrochloride) ()
SCV 07 (hydrochloride) ()
Gamma-D-glutamyl-L-tryptophan (hydrochloride) ()
Golotimod TFA ()
SCV-07 ()
Golotimod (trifluoroacetate salt) ()
P&D ID
PD008597
CAS
229305-39-9
1029401-59-9
2828433-07-2
Tags
available
drug candidate
Drug indication
Inflammation
Immune System disease
chronic hepatitis C virus infection
Drug Status
investigational
Max Phase
2.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Golotimod (SCV 07) is an antimicrobial dipeptide with immunomodulatory activity that significantly improves the efficacy of anti-tuberculosis therapy, induces thymic and splenic cell proliferation, modulates macrophage function, and inhibits STAT3 signaling.Golotimod has been used in the study of recurrent genital Herpes Simplex Virus 2 (HSV-2) infection and oral mucositis.
(TargetMol Bioactive Compound Library)
DESCRIPTION
Golotimod TFA is an immunomodulating peptide that has antimicrobial activity. Golotimod TFA inhibits STAT3 signaling and modulates the duration and severity of oral mucositis in animal models that received radiation or a combination of radiation and Cisplatin.
(BOC Sciences Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
10
AdooQ Bioactive Compound Library
BOC Sciences Bioactive Compounds
Cayman Chemical Bioactives
ChEMBL Drugs
DrugBank
DrugMAP
Pandemic Response Box
ReFrame library
TargetMol Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
33
Molecular Weight
333.13
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
5
Rotatable Bonds
8
Ring Count
2
Aromatic Ring Count
2
cLogP
0.47
TPSA
145.51
Fraction CSP3
0.31
Chiral centers
2.0
Largest ring
6.0
QED
0.47
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
antibiotic
Bacterial
STAT
Pathway
Microbiology/virology
Anti-infection
JAK/STAT Signaling
Stem Cell/Wnt
Source data
