General
Preferred name
Azaguanine-8
Synonyms
8-AZAGUANINE ()
NSC-749 ()
SF-337 ()
SK 1150 ()
ML068 ()
NSC-749, SF-337, SK 1150 ()
P&D ID
PD008585
CAS
134-58-7
Tags
drug candidate
natural product
probe
available
Drug indication
Discovery agent
Drug Status
experimental
Probe info
Probe type
experimental probe
Probe sources
Probe targets
[[ compound.targets[t].gene_name ]]
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Identify small-molecule modulators of Beta-Globin splicing by high throughput screening of chemical libraries.
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
1
Organisms
2
Compound Sets
12
AdooQ Bioactive Compound Library
Drug Repurposing Hub
DrugBank
DrugMAP
DrugMatrix
EU-OPENSCREEN Bioactive Compound Library
MedChem Express Bioactive Compound Library
NIH Mechanistic Set
Prestwick Chemical Library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
43
Molecular Weight
152.04
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
3
Rotatable Bonds
0
Ring Count
2
Aromatic Ring Count
2
cLogP
-1.38
TPSA
113.34
Fraction CSP3
0.0
Chiral centers
0.0
Largest ring
6.0
QED
0.43
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
Purine nucleoside phosphorylase
PNP
Endogenous Metabolite
Nucleoside antimetabolite/analog
DNA/RNA Synthesis
MOA
purine antagonist
Pathway
Cell Cycle/DNA Damage
Metabolic Enzyme/Protease
Source data
