General
Preferred name
KYNURENINE
Synonyms
(S)-Kynurenine ()
L-Kynurenine ()
L-Kynurenine-d4 ()
P&D ID
PD008579
CAS
2922-83-0
2672568-86-2
Tags
available
drug candidate
Drug Status
experimental
investigational
Max Phase
1.0
Drug indication
Headache
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
L-Kynurenine is a metabolite of the amino acid L-tryptophan. L-Kynurenine is an aryl hydrocarbon receptor agonist.
PRICE
29
DESCRIPTION
High affinity PPARgamma ligand; blocks Cdk5-dependent PPARgamma phosphorylation
(Tocris Bioactive Compound Library)
DESCRIPTION
L-Kynurenine ((S)-Kynurenine) is a key intermediate in the breakdown pathway of tryptophan. L-Kynurenine is a substrate of kynureninase, KMO, and KAT associated with the suppression of antitumor immune responses. It has been shown to inhibit allogeneic T-cell proliferation and to increase malignant U87 glioma cell invasion into a collagen matrix.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
8
ChEMBL Drugs
Drug Repurposing Hub
DrugBank
MedChem Express Bioactive Compound Library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
Tocris Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
40
Molecular Weight
208.08
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
3
Rotatable Bonds
4
Ring Count
1
Aromatic Ring Count
1
cLogP
0.25
TPSA
106.41
Fraction CSP3
0.2
Chiral centers
1.0
Largest ring
6.0
QED
0.49
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
AHR
Aryl hydrocarbon receptor
Endogenous Metabolite
Human Endogenous Metabolite
Primary Target
Aryl Hydrocarbon Receptors
MOA
AhR
Ligand
aryl hydrocarbon receptor agonist
Pathway
Immunology/Inflammation
Metabolic Enzyme/Protease
Metabolism
Source data
