General
Preferred name
ISATIN
Synonyms
Indoline-2,3-dione ()
2,3-Indolinedione ()
Pseudoisatin ()
1H-Indole-2,3-dione ()
Indole-2,3-dione ()
P&D ID
PD008558
CAS
5815-00-9
91-56-5
Tags
available
covalent binder
drug candidate
Drug indication
Discovery agent
Drug Status
experimental
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Isatin (Indoline-2,3-dione) is a potent inhibitor of monoamine oxidase (MAO) with an IC50 of 3 ¦ÌM. Also binds to central benzodiazepine receptors (IC50 against clonazepam, 123 ¦ÌM)[1]. Also acts as an antagonist of both atrial natriuretic peptide stimulated and nitric oxide-stimulated guanylate cyclase activity[2]. Shows effect on the serotonergic system[3].
PRICE
29
DESCRIPTION
Indoline-2,3-dione is a potent inhibitor of monoamine oxidase.
(Enamine Bioactive Compounds)
DESCRIPTION
Isatin is an indole derivative used as an intermediate. It also acts as an endogenous MAO inhibitor with an IC50 value of 15 μM.
(BOC Sciences Bioactive Compounds)
DESCRIPTION
Isatin (2,3-Indolinedione) is an endogenous MAO inhibitor.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
2
Organisms
0
Compound Sets
8
BOC Sciences Bioactive Compounds
DrugBank
DrugMAP
Enamine Bioactive Compounds
MedChem Express Bioactive Compound Library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
37
Molecular Weight
147.03
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
1
Rotatable Bonds
0
Ring Count
2
Aromatic Ring Count
1
cLogP
0.82
TPSA
46.17
Fraction CSP3
0.0
Chiral centers
0.0
Largest ring
6.0
QED
0.55
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
Apoptosis
Metabolism
Neuroscience
Neuronal Signaling
MOA
MAO inhibitor
Target
Monoamine Oxidase
MAO
Source data
