General
Preferred name
N,N-dimethylarginine
Synonyms
N^G,N^G-Dimethylarginine hydrochloride ()
Asymmetric dimethylarginine ()
NG,NG-Dimethylarginine ()
NG,NG-dimethyl-L-arginine hydrochloride ()
NG,NG-dimethyl-L-arginine ()
NG,NG-dimethyl-L-Arginine (hydrochloride) ()
NG,NG-dimethyl-L-Arginine-d6 (hydrochloride) ()
NG,NG-dimethyl-L-Arginine ()
P&D ID
PD008499
CAS
220805-22-1
30315-93-6
63937-30-4
1313730-20-9
Tags
drug candidate
natural product
available
Drug indication
Discovery agent
Drug Status
experimental
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
NG,NG-dimethyl-L-arginine (ADMA) is an endogenous nitric oxide synthase (NOS) inhibitor. ADMA interferes with L-arginine in the production of nitric oxide (NO), a key chemical involved in normal endothelial function and, by extension, cardiovascular health.
(BOC Sciences Bioactive Compounds)
DESCRIPTION
Reversible inhibitor of nitric oxide synthetase in vivo and in vitro
(LOPAC library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
9
BOC Sciences Bioactive Compounds
Drug Repurposing Hub
DrugBank
DrugMAP
Guide to Pharmacology
LOPAC library
MedChem Express Bioactive Compound Library
ReFrame library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
60
Molecular Weight
202.14
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
3
Rotatable Bonds
5
Ring Count
0
Aromatic Ring Count
0
cLogP
-0.95
TPSA
104.94
Fraction CSP3
0.75
Chiral centers
1.0
Largest ring
0.0
QED
0.3
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Selectivity
NOS
Target
NOS2, NOS3
Endogenous Metabolite
NO Synthase
MOA
nitric oxide synthase inhibitor
Pathway
Immunology/Inflammation
Metabolic Enzyme/Protease
Source data
