General
Preferred name
LEUCINE
Synonyms
Leu ()
(S)-Leucine ()
L-(1-13C)Leucine ()
(1-13C)Leucine ()
L-leucine ()
(S)-Leucine, Leu ()
L-Leucine-1-13C ()
FEMA NO. 3297 ()
E641 ()
Leucine, l ()
Leucina ()
NSC-46709 ()
L-Leucine-d10 ()
P&D ID
PD008452
CAS
25248-98-0
21675-61-6
71000-80-1
70-45-1
61-90-5
74292-94-7
106972-44-5
Tags
available
drug
Approved by
FDA
Drug indication
Discovery agent
sarcopenia
Drug Status
approved
investigational
nutraceutical
Max Phase
3.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PRICE
29
DESCRIPTION
L-Leucine is an essential branched-chain amino acid. It inhibits voltage-gated calcium channel (alpha 2 delta), IC50 = 61.3 nM.
(Enamine Bioactive Compounds)
DESCRIPTION
L-Leucine ((S)-Leucine) is one of nine essential amino acids in humans (provided by food), L-Leucine is important for protein synthesis and many metabolic functions. L-Leucine contributes to regulation of blood-sugar levels; growth and repair of muscle and bone tissue; growth hormone production; and wound healing. L-Leucine also prevents breakdown of muscle proteins after trauma or severe stress and may be beneficial for individuals with phenylketonuria. L-Leucine is available in many foods and deficiency is rare.
(TargetMol Bioactive Compound Library)
DESCRIPTION
L-Leucine-1-13C (L-Leucine-13C) is a 13C-labeled L-Leucine that significantly enhances the affinity of GLP-4.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
19
ChEMBL Drugs
Concise Guide to Pharmacology 2017/18
Concise Guide to Pharmacology 2019/20
Concise Guide to Pharmacology 2021/22
Concise Guide to Pharmacology 2023/24
Drug Repurposing Hub
DrugBank
DrugCentral
DrugCentral Approved Drugs
DrugMAP
Enamine Bioactive Compounds
Enamine BioReference Compounds
Guide to Pharmacology
LSP-MoA library (Laboratory of Systems Pharmacology)
MedChem Express Bioactive Compound Library
NPC Screening Collection
Selleckchem Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
83
Molecular Weight
131.09
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
2
Rotatable Bonds
3
Ring Count
0
Aromatic Ring Count
0
cLogP
0.44
TPSA
63.32
Fraction CSP3
0.83
Chiral centers
1.0
Largest ring
0.0
QED
0.58
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
MOA
mTOR
Target
BCAT1, BCAT2, LARS, LARS2, LCMT1, LCMT2
Endogenous Metabolite
MTOR
Pathway
PI3K/Akt/mTOR signaling
Metabolism
Metabolic Enzyme/Protease
PI3K/Akt/mTOR
Source data
