General
Preferred name
Glycerol 2-phosphate
Synonyms
Sodium glycerophosphate ()
BETA-GLYCEROL PHOSPHATE DISODIUM SALT ()
??-Glycerophosphate disodium salt pentahydrate ()
??-Glycerol phosphate disodium salt pentahydrate ()
??-Glycerophosphate disodium salt hydrate ()
¦Â-Glycerophosphate disodium salt hydrate ()
Glycerophosphoric acid (disodium salt hydrate) ()
??Glycerophosphate sodium salt hydrate ()
Glycerol-2-Phosphate ()
β-Glycerophosphate sodium salt hydrate ()
??-Glycerophosphate sodium salt hydrate ()
??-Glycerophosphate (disodium salt hydrate) ()
Calcium glycerophosphate ()
glycerol 3-phosphate ()
1-glycerophosphate ()
Glycerophosphoric acid ()
GLYCERYL 1-PHOSPHATE ()
Dl-.alpha.-glycerophosphoric acid ()
Dl-.alpha.-glycerol phosphate ()
3-glycerophosphate ()
Glycerol 1-phosphate ()
Glyceryl 1-phosphoric acid ()
Dl-.alpha.-glyceryl phosphate ()
Dl-glycerol 3-phosphate ()
1-glycerophosphoric acid ()
Glycerophosphate ()
Glyceryl phosphate ()
Dl-.alpha.-glycerophosphate ()
Dl-glycerol 1-phosphate ()
NSC-9231 ()
GLYCERYLPHOSPHATE ()
CALCIUM GLYCERYLPHOSPHATE ()
Glycerophosphate (sodium salt hydrate) ()
?-Glycerophosphate-d5 (sodium salt hydrate) ()
?-Glycerophosphate (sodium salt hydrate) ()
P&D ID
PD008431
CAS
13408-09-8
154804-51-0
17181-54-3
58409-70-4
Tags
available
drug
drug candidate
Drug indication
Discovery agent
Drug Status
approved
experimental
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PHARMACODYNAMICS It is thought that calcium glycerophosphate may act through a variety of mechanisms to produce an anti-caries effect [A27153]. These include increasing acid-resistance of the enamel, increasing enamel mineralization, modifying plaque, acting as a pH-buffer in plaque, and elevating [DB01373] and phosphate levels. ; ; When used as an electrolyte replacement, calcium glycerophosphate donates [DB01373] and inorganic phosphate. Calcium glycerophosphate is preferable to calcium phosphate due to its increased solubility. Compared to combination calcium gluconate and potassium phosphate, calcium glycerophosphate produces greater phosphate retention which allows for increased [DB01373] retention and ultimately greater incorporation of the ions into bone structure [A27152].
INDICATION Calcium glycerophosphate is found in OTC dental products such as toothpastes for the prevention of dental caries. As OTC products these do not have an official indication.; ; In prescription products it is indicated as a [DB01373] or phosphate donor for replacement or supplementation in patients with insufficient [DB01373] or phosphate.
MOA Calcium glycerophosphate in combination with sodium monofluorophosphate was found to reduce the acid solubility of enamel. This is thought to be due to increased uptake of fluoride in a non-alkali soluble form at the expense of a fraction remaining in the alkali-soluble form of calcium fluoride [A27153]. It is also thought that calcium glycerophosphate enhances the remineralization effect of sodium monofluorophosphate leading to greater remineralization of enamel but the mechanism behind this is unknown.; ; Calcium glycerophosphate reduces the decrease in plaque pH produced by sucrose solutions [A27153]. This may be due to the buffering action of donated phosphate which acts as an acceptor to three hydrogen ions to form biphosphate, dihydrogen phosphate, and finally phosphoric acid. As bisphosphate and dihydrogen phosphate are amphoteric, these molecules can act as buffers against both acids and bases.; ; Studies on plaque-modification by calcium glycerophosphate have been inconsistent [A27153]. Redections in plaque weight and plaque area have been noted in separate studies but neither has been confirmed and no causative link has been established in regards to calcium glycerophosphate's anti-caries effect.; ; Calcium glycerophosphate donates [DB01373] and inorganic phosphate resulting in elevated levels of the ions in plaque [A27153]. These ions are important components of the mineral structure of teeth. As such, their presence supports maintenance of healthy tooth structure and mineralization.; ; In electrolyte replacement calcium glycerophosphate again acts as a donor of [DB01373] and phosphate. See [DB11348] for pharmacological descriptions of calcium and phosphate.
DESCRIPTION β-Glycerophosphate is a protein phosphatase inhibitor that can be used as a phosphate group donor in matrix mineralization studies. (BOC Sciences Bioactive Compounds)
Compound Sets
11
BOC Sciences Bioactive Compounds
glycerophosphoric-acid-disodium-salt-pentahydrate-cas-13408-09-8-item-14030
Cayman Chemical Bioactives
38367
34516
14405
ChEMBL Drugs
CHEMBL1232903
CHEMBL3707206
Drug Repurposing Hub
DrugBank
DB01779
DB11264
DrugBank Approved Drugs
DB11264
DrugMAP
DM0J5KF
NPC Screening Collection
Other bioactive compounds
Selleckchem Bioactive Compound Library
beta-glycerophosphate-sodium-salt-hydrate
beta-glycerophosphate-disodium-salt-hydrate
TargetMol Bioactive Compound Library
T5878
T4915
External IDs
80
Properties
(calculated by RDKit )
Molecular Weight
172.01
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
4
Rotatable Bonds
4
Ring Count
0
Aromatic Ring Count
0
cLogP
-1.55
TPSA
107.22
Fraction CSP3
1.0
Chiral centers
0.0
Largest ring
0.0
QED
0.38
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
phosphatase
Endogenous Metabolite
Pathway
Metabolic Enzyme/Protease
Source data