General
Preferred name
PP1
Synonyms
PP 1 ()
EI 275 ()
AGL 1872 ()
PP-1 ()
AGL 1872, EI 275 ()
1-Ter-Butyl-3-P-Tolyl-1h-Pyrazolo[3,4-D]Pyrimidin-4-Ylamine ()
PP1 (Src Inhibitor) ()
P&D ID
PD008408
CAS
172889-26-8
Tags
available
drug candidate
Drug Status
experimental
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION PP1 is a multi-kinase inhibitor. (GtoPdb)
DESCRIPTION PP1 is a potent, and Src family-selective tyrosine kinase inhibitor with IC50 of 5 and 6 nM for Lck and Fyn, respectively.
PRICE 86
DESCRIPTION GSK-3beta inhibitor; also inhibits cdks (Tocris Bioactive Compound Library)
DESCRIPTION Potent, selective Src inhibitor (Tocriscreen Total)
DESCRIPTION PP1 is a potent, reversible, ATP-competitive, and selective inhibitor of the Src family of protein tyrosine kinases. It inhibits p56lck (IC50 = 5 nM), p59fynT (IC50 = 6 nM), Hck (IC50 = 20 nM), and Src (IC50 = 170 nM) without significantly affecting the activity of EGFR kinase (IC50 = 250 nM), JAK2 (IC50 = 50 µM), or ZAP-70 (IC50 ≥ 0.6 µM). (BOC Sciences Bioactive Compounds)
DESCRIPTION PP1 (AGL 1872), a specific and effective Src inhibitor, is with IC50 for Lck/Fyn is 5 nM/ 6 nM, respectively. (TargetMol Bioactive Compound Library)
Cell lines
5
Organisms
0
Compound Sets
21
AdooQ Bioactive Compound Library
A12724
BOC Sciences Bioactive Compounds
pp1-cas-172889-26-8-item-84-195954
Cayman Chemical Bioactives
14244
Concise Guide to Pharmacology 2017/18
8836
Concise Guide to Pharmacology 2019/20
8836
Concise Guide to Pharmacology 2021/22
8836
Concise Guide to Pharmacology 2023/24
8836
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugBank
DB01809
DrugMatrix
EU-OPENSCREEN Bioactive Compound Library
EOS101449
Guide to Pharmacology
8836
JUMP-Target 1 Compound Set
1400
LINCS compound set
10405-101
MedChem Express Bioactive Compound Library
HY-13804
Novartis Chemogenetic Library (NIBR MoA Box)
Selleckchem Bioactive Compound Library
pp1
TargetMol Bioactive Compound Library
T6196
Tocris Bioactive Compound Library
1397
Tocriscreen Total
External IDs
24
Properties
(calculated by RDKit )
Molecular Weight
281.16
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
1
Rotatable Bonds
1
Ring Count
3
Aromatic Ring Count
3
cLogP
3.14
TPSA
69.62
Fraction CSP3
0.31
Chiral centers
0.0
Largest ring
6.0
QED
0.74
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
Apoptosis
Bcr-Abl
EGFR
Fyn
KIT
LCK
SRC
HCK, RET
Hck
Primary Target
Src Kinases
MOA
Inhibitor
Apoptosis Inducers
Src Kinase Inhibitors
Inhibitors of Signal Transduction Pathways
Abl Kinase Inhibitors
"Apoptosis Inducers
Abl Kinase Inhibitors"
Src inhibitor
Member status
virtual
Pathway
Angiogenesis
Cytoskeletal Signaling
JAK/STAT Signaling
Tyrosine Kinase/Adaptors
Protein Tyrosine Kinase/RTK
Source data