General
Preferred name
PUTRESCINE
Synonyms
PUTRESCINE DIHYDROCHLORIDE ()
NSC 60545 ()
Putramine ()
1,4-butanediamine Dihydrochloride ()
Tetramethylenediamine ()
1,4-Tetramethylenediamine ()
Putrascine ()
Putrescine dihydrochloride, Tetramethylenediamine dihydrochloride, 1,4-Butanediamine dihydrochloride ()
1,4-Diaminobutane dihydrochloride ()
NSC-60545 ()
1,4-Diaminobutane ()
P&D ID
PD008302
CAS
333-93-7
110-60-1
29142-66-3
Tags
available
drug candidate
Drug indication
Burn and burn infection
severe cutaneous adverse reaction
Drug Status
experimental
investigational
Max Phase
3.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PRICE
29
DESCRIPTION
Binds to the polyamine modulatory site of the NMDA glutamate receptor and potentiates NMDA-induced currents; precursor of spermidine
(LOPAC library)
DESCRIPTION
1,4-Diaminobutane Dihydrochloride (1,4-butanediamine Dihydrochloride) has antidepressant and analgesic effects. It regulates plant defense against environmental stresses by directly killing fungi and inducing resistance mechanisms, enhancing post-harvest mango fruit resistance to Colletotrichum gloeosporioides.
(TargetMol Bioactive Compound Library)
DESCRIPTION
1,4-diaminobutane is an enzyme-activated inhibitor of ornithine decarboxylase.
(Enamine Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
2
Organisms
0
Compound Sets
16
Cayman Chemical Bioactives
ChEMBL Drugs
Concise Guide to Pharmacology 2017/18
Concise Guide to Pharmacology 2019/20
Concise Guide to Pharmacology 2021/22
Concise Guide to Pharmacology 2023/24
Drug Repurposing Hub
DrugBank
DrugMAP
Enamine Bioactive Compounds
Guide to Pharmacology
LOPAC library
ReFrame library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
The Spectrum Collection
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
58
Molecular Weight
88.1
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
2
Rotatable Bonds
3
Ring Count
0
Aromatic Ring Count
0
cLogP
-0.32
TPSA
52.04
Fraction CSP3
1.0
Chiral centers
0.0
Largest ring
0.0
QED
0.46
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
Metabolic Enzyme/Protease
Metabolism
Selectivity
NMDA-Polyamine
Target
Endogenous Metabolite
Human Endogenous Metabolite
AMD1, KCNJ4, ODC1
MOA
Tissue transglutaminase inhibitor
Source data
