General
Preferred name
GPI-1046
Synonyms
P&D ID
PD008273
CAS
186452-09-5
Tags
available
drug candidate
Drug indication
Parkinson disease
Drug Status
experimental
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION GPI-1046 is an orally active, antibiotic-free immunophilin ligand that reduces ethanol intake by upregulating glutamate transporter 1 (GLT1) in the prefrontal cortex (PFC) and nucleus accumbens core (NAc-core). GPI-1046 improves human immunodeficiency virus (HIV)-associated sensory neuropathy (HIV-SN) by attenuating store-operated calcium (SOC) entry. GPI-1046 has neuroprotective activity [1][2][3].
PRICE 191
DESCRIPTION GPI-1046 was originally described to bind FKBP12 , but it has higher affinity for FKBP38 . (GtoPdb)
DESCRIPTION GPI-1046 is an immunophilin ligand without antibiotic action and attenuates ethanol intake in part through the upregulation of glutamate transporter 1 (GLT1) in PFC and NAc-core. (TargetMol Bioactive Compound Library)
Compound Sets
11
AdooQ Bioactive Compound Library
A13015
Concise Guide to Pharmacology 2021/22
11483
Concise Guide to Pharmacology 2023/24
11483
Drug Repurposing Hub
DrugBank
DB01951
DrugMAP
DMD5WK4
Guide to Pharmacology
11483
MedChem Express Bioactive Compound Library
HY-124619
Novartis Chemogenetic Library (NIBR MoA Box)
ReFrame library
TargetMol Bioactive Compound Library
T11451
External IDs
21
Properties
(calculated by RDKit )
Molecular Weight
360.2
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
0
Rotatable Bonds
8
Ring Count
2
Aromatic Ring Count
1
cLogP
2.55
TPSA
76.57
Fraction CSP3
0.6
Chiral centers
1.0
Largest ring
6.0
QED
0.4
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Target
FKBP
HIV
FKBP1A
EAAT
Member status
member
MOA
FK506-Binding Protein 12 (Peptidyl-Prolyl Cis-Trans Isomerase FKBP12) Inhibitors
Neurotrophic Agents
Rotamase (FKBP12) Inhibitors
FKBP inhibitor
Pathway
Anti-infection
Membrane Transporter/Ion Channel
Microbiology/virology
Proteases/Proteasome
Source data