General
Preferred name
R048-8071
Synonyms
Ro 48-8071 fumarate ()
Ro48-8071 ()
Ro 48-8071 (fumarate) ()
Ro 48-8071 ()
P&D ID
PD008220
CAS
189197-69-1
161582-11-2
Tags
available
drug candidate
Drug indication
Discovery agent
Drug Status
experimental
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Ro 48-8071 fumarate is an inhibitor of OSC (Oxidosqualene cyclase) with IC50 of appr 6.5 nM.
PRICE 70
DESCRIPTION PCNA inhibitor (Tocris Bioactive Compound Library)
DESCRIPTION 2,3-Oxidosqualene cyclase (OSC) inhibitor (Tocriscreen Plus)
DESCRIPTION Ro 48-8071 is an orally active cholesterol synthesis inhibitor or a 2,3-oxidosqualene:lanosterol cyclase (OSC) inhibitor. OSC (EC 5.4.99.7) represents a unique target for a cholesterol-lowering drug. Partial inhibition of OSC should reduce synthesis of lanosterol and subsequent sterols, and also stimulate the production of epoxysterols that repress HMG-CoA reductase expression, generating a synergistic, self-limited negative regulatory loop. (BOC Sciences Bioactive Compounds)
DESCRIPTION Ro 48-8071 fumarate, an inhibitor of OSC (Oxidosqualene cyclase; IC50=6.5 nM), exhibits LDL (low-density lipoprotein) cholesterol-lowering activity. (TargetMol Bioactive Compound Library)
DESCRIPTION Ro 48-8071 is an orally active cholesterol synthesis inhibitor or a 2,3-oxidosqualene:lanosterol cyclase (OSC) inhibitor. OSC (EC 5.4.99.7) represents a unique target for a cholesterol-lowering drug. Partial inhibition of OSC should reduce synthesis of lanosterol and subsequent sterols, and also stimulate the production of epoxysterols that repress HMG-CoA reductase expression, generating a synergistic, self-limited negative regulatory loop. (BOC Sciences Bioactive Compounds)
Cell lines
6
Organisms
0
Compound Sets
17
AdooQ Bioactive Compound Library
A14321
BOC Sciences Bioactive Compounds
ro-48-8071-fumarate-cas-189197-69-1-item-84-283338
ro-48-8071-cas-161582-11-2-item-84-212054
Cayman Chemical Bioactives
10006415
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugBank
DB02016
DrugMAP
DMVGITD
EU-OPENSCREEN Bioactive Compound Library
EOS101544
Guide to Pharmacology
6710
Mcule NIBR MoA Box Subset
MCULE-3362163091
MedChem Express Bioactive Compound Library
HY-18630A
Novartis Chemogenetic Library (NIBR MoA Box)
Other bioactive compounds
TargetMol Bioactive Compound Library
T1771
Tocris Bioactive Compound Library
5389
Tocriscreen Plus
5389
ZINC Tool Compounds
ZINC000002563947
External IDs
45
Properties
(calculated by RDKit )
Molecular Weight
447.12
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
0
Rotatable Bonds
12
Ring Count
2
Aromatic Ring Count
2
cLogP
5.88
TPSA
29.54
Fraction CSP3
0.35
Chiral centers
0.0
Largest ring
6.0
QED
0.23
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target Type
Cell Biology
Target
Oxidosqualene cyclase
LSS
Primary Target
Other Lipid Metabolism
MOA
Inhibitor
lanosterol synthetase inhibitor
Oxidosqualene cyclase inhibitor
Member status
member
Source data