General
Preferred name
PLATELET ACTIVATING FACTOR
Synonyms
PAF ()
C16-PAF ()
PAF (C16) ()
[3H]PAF ()
PAF C-16 ()
PAF C-16-d4 ()
P&D ID
PD008094
CAS
74389-68-7
211106-54-6
Tags
available
drug candidate
Drug indication
Discovery agent
Drug Status
experimental
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION PAF is an endogenous platelet-activating factor; PAF receptor agonist. PAF-PAFR signalling plays a role in a wide range of biological processes including vasodilation, superoxide formation, cell proliferation, angiogenesis and regulation of the inflammatory response. (GtoPdb)
DESCRIPTION PAF is an endogenous platelet-activating factor; PAF receptor agonist.
DESCRIPTION PAF (C16) is an endogenous platelet-activating factor (PAF). It can induce increased vascular permeability. (BOC Sciences Bioactive Compounds)
Compound Sets
10
BOC Sciences Bioactive Compounds
paf-c16-cas-74389-68-7-31903
Cayman Chemical Bioactives
360900
60900
Concise Guide to Pharmacology 2017/18
1833
Concise Guide to Pharmacology 2019/20
1833
Concise Guide to Pharmacology 2021/22
1833
Concise Guide to Pharmacology 2023/24
1833
DrugBank
DB02261
DrugMAP
DMRZAQW
Guide to Pharmacology
1831
1833
MedChem Express Bioactive Compound Library
HY-108635
External IDs
28
Properties
(calculated by RDKit )
Molecular Weight
523.36
Hydrogen Bond Acceptors
7
Hydrogen Bond Donors
0
Rotatable Bonds
25
Ring Count
0
Aromatic Ring Count
0
cLogP
5.62
TPSA
94.12
Fraction CSP3
0.96
Chiral centers
2.0
Largest ring
0.0
QED
0.07
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
MAPK/ERK Pathway
Metabolic Enzyme/Protease
Stem Cell/Wnt
Target
Endogenous Metabolite
ERK
MEK
p38 MAPK
Solubility
Soluble in water (100 mM), ethanol (100 mM), chloroform, DMSO (~10 mg/ml), DMF (~10 mg/ml), and PBS (pH 7.2) (~25 mg/ml).
Source data