General
Preferred name
BIVALIRUDIN
Synonyms
Hirulog-1 ()
BG-8967 ()
Angiomax ()
bivalrudin ()
Bivalirudin Trifluoroacetate ()
Bivalirudin in 0.9% sodium chloride ()
BG8967 ()
Angiomax rtu ()
Angiox ()
P&D ID
PD008021
CAS
128270-60-0
Tags
available
drug candidate
drug
Approved by
FDA
First approval
2000
Drug Status
investigational
approved
Drug indication
Thrombocytopenia
Antithrombotic
Anticoagulant
Max Phase
Phase 4
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Bivalirudin is a peptide congener of hirudin, the naturally occurring anticoagulant found in the saliva of the medicinal leech Hirudo medicinalis. (GtoPdb)
Compound Sets
16
AdooQ Bioactive Compound Library
A15023
Cayman Chemical Bioactives
23035
ChEMBL Approved Drugs
CHEMBL2103749
ChEMBL Drugs
CHEMBL2103749
CHEMBL3989957
Drug Repurposing Hub
DrugBank
DB00006
DrugBank Approved Drugs
DB00006
DrugCentral
385
DrugCentral Approved Drugs
385
DrugMAP
DMECRX1
DrugMAP Approved Drugs
DMECRX1
Guide to Pharmacology
6470
MedChem Express Bioactive Compound Library
HY-P1929
Natural product-based probes and drugs
ReFrame library
TargetMol Bioactive Compound Library
T5519
External IDs
39
Properties
(calculated by RDKit )
Molecular Weight
2178.99
Hydrogen Bond Acceptors
29
Hydrogen Bond Donors
28
Rotatable Bonds
66
Ring Count
6
Aromatic Ring Count
3
cLogP
-8.12
TPSA
901.57
Fraction CSP3
0.54
Chiral centers
16.0
Largest ring
6.0
QED
0.01
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
Proteases/Proteasome
Metabolic Enzyme/Protease
Target
Thrombin
F2
Indication
angina pectoris
MOA
Thrombin inhibitor
Biosynthetic Origin
Peptide (Ribosomal)
Therapeutic Indication
Antithrombotic
Therapeutic Class
Cardiovascular
Antithrombotic Agents
Source data