General
Preferred name
K201 free base
Synonyms
JTV-519 (free base) ()
JTV 519 fumarate ()
K201 (free base) ()
K-201 ()
P&D ID
PD007948
CAS
1883549-36-7
1038410-88-6
Tags
available
drug candidate
Drug indication
Atopic dermatitis
Drug Status
investigational
experimental
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Positive allosteric modulator of alpha7 nAChRs
(Tocris Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
5
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
29
Molecular Weight
424.22
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
0
Rotatable Bonds
6
Ring Count
4
Aromatic Ring Count
2
cLogP
4.47
TPSA
32.78
Fraction CSP3
0.48
Chiral centers
0.0
Largest ring
7.0
QED
0.68
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
Calcium Channel
Pathway
Membrane Transporter/Ion Channel
Neuronal Signaling
Primary Target
Ryanodine Receptors
MOA
Inhibitor
RyR2/FKBP12.6 Complex Antagonists
Calcium Channel Blockers
Member status
member
Source data
