General
Preferred name
FEXARAMINE
Synonyms
P&D ID
PD007878
CAS
574013-66-4
Tags
available
drug candidate
Drug indication
Discovery agent
Drug Status
experimental
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Fexaramine is a potent and selective FXR agonist with an EC50 of 25 nM. Fexaramine has no activity against hRXR¦Á, hPPAR¦Á¦Ã¦Ä, mPXR, hPXR, hLXR¦Á, hTR¦Â, hRAR¦Â, mCAR, mERR¦Ã, and hVDR receptors[1][2].
PRICE
96
DESCRIPTION
Potent, selective farnesoid X receptor (FXR) agonist
(Tocriscreen Plus)
DESCRIPTION
Potent, selective farnesoid X receptor (FXR) agonist
(Tocriscreen Total)
DESCRIPTION
Selective ERbeta antagonist
(Tocris Bioactive Compound Library)
DESCRIPTION
Fexaramine is a small molecule farnesoid X receptor (FXR) agonist with 100-fold increased affinity compared to natural compounds.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
22
AdooQ Bioactive Compound Library
Cayman Chemical Bioactives
Concise Guide to Pharmacology 2017/18
Concise Guide to Pharmacology 2019/20
Concise Guide to Pharmacology 2021/22
Concise Guide to Pharmacology 2023/24
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugBank
DrugMAP
EU-OPENSCREEN Bioactive Compound Library
EUbOPEN Chemogenomics Library
Guide to Pharmacology
Mcule NIBR MoA Box Subset
MedChem Express Bioactive Compound Library
Novartis Chemogenetic Library (NIBR MoA Box)
NURSA ligand set
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
Tocris Bioactive Compound Library
Tocriscreen Plus
Tocriscreen Total
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
23
Molecular Weight
496.27
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
0
Rotatable Bonds
8
Ring Count
4
Aromatic Ring Count
3
cLogP
6.72
TPSA
49.85
Fraction CSP3
0.31
Chiral centers
0.0
Largest ring
6.0
QED
0.26
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target Type
Nuclear Receptors
Primary Target
LXR-like Receptors
MOA
Agonist
Farnesoid X-receptor agonist
FXR agonist
Member status
member
Target
NR1H4
FXR
Pathway
Autophagy
Metabolism
Metabolic Enzyme/Protease
Recommended Cell Concentration
1 uM
Source data
