General
Preferred name
PELDESINE
Synonyms
BCX 34 ()
Peldesine (dihydrochloride) ()
BCX 34 (dihydrochloride) ()
BCX-34 ()
Peldesina ()
P&D ID
PD007859
CAS
133432-71-0
2772702-10-8
Tags
available
drug candidate
Drug Status
investigational
Max Phase
2.0
Drug indication
HIV infection
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PRICE 281
DESCRIPTION Peldesine (BCX 34) dihydrochloride is a potent, competitive, reversible and orally active purine nucleoside phosphorylase (PNP) inhibitor with IC50s of 36 nM, 5 nM, and 32 nM for human, rat, and mouse red blood cell (RBC) PNP, respectively. Peldesine dihydrochloride is also a T-cell proliferation inhibitor with an IC50 of 800 nM. Peldesine dihydrochloride has the potential for cutaneous T-cell lymphoma, psoriasis and HIV infection research[1][2][3][4].
DESCRIPTION Peldesine (BCX 34) is an effective, competitive, reversible, and orally active inhibitor of purine nucleoside phosphorylase. Peldesine inhibits T-cell proliferation with an IC50 of 800 nM. Peldesine can be used in research on cutaneous T-cell lymphoma, psoriasis and HIV infection. (TargetMol Bioactive Compound Library)
Compound Sets
8
ChEMBL Drugs
CHEMBL311300
DrugBank
DB02568
DrugMAP
DMHV58T
DrugMatrix
MedChem Express Bioactive Compound Library
HY-106934A
Pandemic Response Box
ReFrame library
TargetMol Bioactive Compound Library
T12399
External IDs
32
Properties
(calculated by RDKit )
Molecular Weight
241.1
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
3
Rotatable Bonds
2
Ring Count
3
Aromatic Ring Count
3
cLogP
0.82
TPSA
100.45
Fraction CSP3
0.08
Chiral centers
0.0
Largest ring
6.0
QED
0.62
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
Purine nucleoside phosphorylase
HIV
Nucleoside antimetabolite/analog
Pathway
Anti-infection
Cell Cycle/DNA Damage
Cell Cycle/Checkpoint
DNA Damage/DNA Repair
Microbiology/virology
Proteases/Proteasome
Source data