General
Preferred name
LGH-447
Synonyms
(1S,3R,5R)-PIM447 (dihydrochloride) ()
(1S,3R,5R)-LGH447 dihydrochloride ()
P&D ID
PD007855
Tags
available
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
(1S,3R,5R)-PIM447 (dihydrochloride) an PIM inhibitor extracted from patent US 20100056576 A1, compound example 72, has IC50 values of 0.095 ¦ÌM for Pim1, 0.522 ¦ÌM for Pim2 and 0.369 ¦ÌM for Pim3.
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[[ compound.targets[tid].gene_name ]]
Compound Sets
2
MedChem Express Bioactive Compound Library
ReFrame library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
10
Molecular Weight
440.18
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
2
Rotatable Bonds
4
Ring Count
4
Aromatic Ring Count
3
cLogP
5.04
TPSA
80.9
Fraction CSP3
0.29
Chiral centers
3.0
Largest ring
6.0
QED
0.6
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
Pim
Pathway
JAK/STAT Signaling
Source data
