General
Preferred name
COLFORSIN
Synonyms
forskolin ()
Coleonol ()
HL 362 ()
Forskolin, HL 362, Coleonol ()
Colforsina ()
Boforsin ()
NSC-357088 ()
L-751362B ()
NSC-375489 ()
L 75 1362B ()
Colforsine ()
L-75-1362B ()
HL-362 ()
Forskolin ()
P&D ID
PD007842
CAS
66575-29-9
66428-89-5
64657-11-0
Tags
available
drug candidate
natural product
Drug indication
Solid tumour/cancer
Drug Status
experimental
investigational
Max Phase
2.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Forskolin (Coleonol) is a potent adenylate cyclase activator with an IC50 of 41 nM and an EC50 of 0.5 ¦ÌM for type I adenylyl cyclase[1]. Forskolin is also an inducer of intracellular cAMP formation[2]. Forskolin induces differentiation of various cell types and activates pregnane X receptor (PXR) and FXR[3]. Forskolin exerts a inotropic effect on the heart, and has platelet antiaggregatory and antihypertensive actions. Forskolin also induces autophagy[4][5].
DESCRIPTION
DNA topoisomerase inhibitor
(Tocris Bioactive Compound Library)
DESCRIPTION
Adenylyl cyclase activator
(Tocriscreen Plus)
DESCRIPTION
Adenylyl cyclase activator
(Tocriscreen Total)
DESCRIPTION
Forskolin is a naturally occurring diterpene that is produced by the Indian Coleus plant. Forskolin is a potent adenylate cyclase activator.
(Enamine Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
1
Organisms
3
Compound Sets
20
AdooQ Bioactive Compound Library
Axon Medchem Screening Library
Cayman Chemical Bioactives
ChEMBL Drugs
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugBank
DrugMAP
Enamine Bioactive Compounds
EU-OPENSCREEN Bioactive Compound Library
Guide to Pharmacology
Mcule NIBR MoA Box Subset
MedChem Express Bioactive Compound Library
Novartis Chemogenetic Library (NIBR MoA Box)
ReFrame library
Selleckchem Bioactive Compound Library
Tocris Bioactive Compound Library
Tocriscreen Plus
Tocriscreen Total
ZINC Tool Compounds
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
43
Molecular Weight
410.23
Hydrogen Bond Acceptors
7
Hydrogen Bond Donors
3
Rotatable Bonds
2
Ring Count
3
Aromatic Ring Count
0
cLogP
1.52
TPSA
113.29
Fraction CSP3
0.82
Chiral centers
8.0
Largest ring
6.0
QED
0.47
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target Type
Enzymes
Primary Target
Adenylyl Cyclases
MOA
AChR
Activator
Adenylate Cyclase Activators
adenylyl cyclase activator
Member status
member
Target
ADCY2, ADCY5, GNAS
ADCY2, ADCY5
Adenylate cyclase activator
Adenylate cyclase
Autophagy
FXR
Organoid
PKC
Autophagy,cAMP,FXR
Pathway
Epigenetics
GPCR/G protein
Metabolic Enzyme/Protease
Stem Cell/Wnt
TGF-beta/Smad
Source data
