General
Preferred name
LY-294002
Synonyms
LY294002 ()
LY 294002 hydrochloride ()
154447-36-6 ()
LY-294,002 hydrochloride ()
LY 294002 ()
NSC 697286 ()
SF 1101 ()
LY294002 hydrochloride ()
LY294002 (NSC 697286 ()
LY-294002 ) ()
LY 294002 HCl ()
LY294002 (hydrochloride) ()
SF 1101, NSC 697286 ()
LY-294002 hydrochloride ()
NSC-697286 ()
SF-1101 ()
P&D ID
PD007784
CAS
154447-36-6
934389-88-5
Tags
available
drug candidate
obsolete probe
Drug indication
Neuroblastoma
Drug Status
experimental
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION LY 294002 is a selective phosphatidylinositol 3-kinase (PI3K) inhibitor , with preference for PI3Kα/δ/β. LY 294002 has also been reported to interact with the unrelated BET bromodomain proteins BRD2, BRD3, and BRD4 . (GtoPdb)
DESCRIPTION LY294002 is a broad-spectrum inhibitor of PI3K with IC50s of 0.5, 0.57, and 0.97 ¦ÌM for PI3K¦Á, PI3K¦Ä and PI3K¦Â, respectively[1]. LY294002 also inhibits CK2 with an IC50 of 98 nM[2]. LY294002 is a competitive DNA-PK inhibitor that binds reversibly to the kinase domain of DNA-PK with an IC50 of 1.4 ¦ÌM. LY294002 is an apoptosis activator[3].
PRICE 37
DESCRIPTION LY294002 (SF 1101) is a broad-spectrum inhibitor of PI3K, inhibiting PI3K??, PI3K??, and PI3K?? (IC50=0.5/0.57/0.97 ??M). LY294002 is also an inhibitor of DNA-PK (IC50=1.4 ??M) and an inhibitor of CK2 (IC50=98 nM). LY294002 activates apoptosis and autophagy.
DESCRIPTION LY294002 hydrochloride is a potent and broad-spectrum PI3K inhibitor, with IC50 values of 0.5, 0.57, and 0.97 ¦ÌM for P110¦Á, P110¦Ä and P110¦Â, respectively. LY294002 hydrochloride also inhibits CK2 with an IC50 of 98 nM. LY294002 hydrochloride can be used for pancreatic cancer research[1][2][3].
PRICE 48
DESCRIPTION LY-294002 hydrochloride (NSC 697286) is a synthetic molecule inhibitor of PI3K??/??/?? (IC50: 0.5/0.57/0.97 ??M, in cell-free assays); more stable than Wortmannin in solution, and also is a blocker of autophagosome formation.
DESCRIPTION LY 294002 is a selective phosphatidylinositol 3-kinase inhibitor. It also inhibits CK2 and competitive DNA-PK. (Enamine Bioactive Compounds)
DESCRIPTION LY294002 (SF 1101) is a broad-spectrum inhibitor of PI3K, inhibiting PI3Kα, PI3Kδ, and PI3Kβ (IC50=0.5/0.57/0.97 μM). LY294002 is also an inhibitor of DNA-PK (IC50=1.4 μM) and an inhibitor of CK2 (IC50=98 nM). LY294002 activates apoptosis and autophagy. (TargetMol Bioactive Compound Library)
DESCRIPTION Potent, selective inhibitor of MEK1 and 2 (Tocris Bioactive Compound Library)
DESCRIPTION Prototypical PI 3-kinase inhibitor; also inhibits other kinases (Tocriscreen Plus)
DESCRIPTION Specific phosphatidylinositol 3-kinase (PI3K) inhibitor. (LOPAC library)
DESCRIPTION Selective PI 3-kinase inhibitor (Tocriscreen Total)
DESCRIPTION LY 294002 hydrochloride is a PI 3-kinase inhibitor with IC50 values of 0.31μM for PI 3-Kβ, 0.73μM for PI 3-Kα, 1.06μM for PI 3-Kδ and 6.60μM for PI 3-Kγ. It can inhibit proliferation and induce apoptosis in human colon cancer cells. (BOC Sciences Bioactive Compounds)
DESCRIPTION LY-294002 hydrochloride (NSC 697286) is a synthetic molecule inhibitor of PI3Kα/δ/β (IC50: 0.5/0.57/0.97 μM, in cell-free assays); more stable than Wortmannin in solution, and also is a blocker of autophagosome formation. (TargetMol Bioactive Compound Library)
Cell lines
57
Organisms
2
Compound Sets
25
AdooQ Bioactive Compound Library
A10547
Axon Medchem Screening Library
1366
BOC Sciences Bioactive Compounds
ly-294002-hydrochloride-cas-934389-88-5-item-156202
Cayman Chemical Bioactives
70920
39171
ChEMBL Drugs
CHEMBL98350
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugBank
DB02656
DrugMAP
DMY1AFS
DrugMatrix
Enamine Bioactive Compounds
EBC-11275
Enamine BioReference Compounds
Guide to Pharmacology
6004
LINCS compound set
10510-101
LOPAC library
MedChem Express Bioactive Compound Library
HY-10108
HY-10108A
NURSA ligand set
nursa/index.jsf?doi=10.1621%2F78BD2792E0
Obsolete Compounds
ly294002
Reference compounds for characterizing cellular injury in high-content cellular morphology assays
ReFrame library
Selleckchem Bioactive Compound Library
LY294002
TargetMol Bioactive Compound Library
T2008
T4079
Tocris Bioactive Compound Library
1130
Tocriscreen Plus
1130
Tocriscreen Total
External IDs
48
Properties
(calculated by RDKit )
Molecular Weight
307.12
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
0
Rotatable Bonds
2
Ring Count
4
Aromatic Ring Count
3
cLogP
3.3
TPSA
42.68
Fraction CSP3
0.21
Chiral centers
0.0
Largest ring
6.0
QED
0.73
Structural alerts
1
historic compounds (Chemical Probes.org)
Obsolete
Related compounds
Custom attributes
(extracted from source data)
Target Type
Enzymes
Selectivity
PI3K
Target
p110α
p110β
p110δ
AKT1, CHEK1, GSK3B, LCK, MAPK1, MAPK11, MAPK12, MAPK14, MAPK8, MTOR, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIM1, PLK1, PRKCA, PRKDC, ROCK1, RPS6KB1, SGK1
PI3K inhibitor
Apoptosis related,Autophagy,Casein Kinase,DNA-PK,PI3K
Casein kinase
DNA-PK
Primary Target
PI 3-kinase
MOA
Inhibitor
DNA dependent protein kinase inhibitor, mTOR inhibitor, phosphodiesterase inhibitor, PI3K inhibitor, PLK inhibitor
Cellular injury category
Kinase
Pathway
Apoptosis
Autophagy
DNA Damage/DNA Repair
Metabolism
PI3K/Akt/mTOR signaling
Stem Cells
Cell Cycle/DNA Damage
PI3K/Akt/mTOR
Stem Cell/Wnt
Source data