General
Preferred name
CYSTEINE
Synonyms
(R)-CYSTEINE ()
L-cysteine ()
Thioserine ()
L-(+)-Cysteine ()
L-Cysteine hydrochloride monohydrate ()
L-Cysteine (hydrochloride hydrate) ()
L-Cysteine (hydrochloride) ()
CYSTEINE HYDROCHLORIDE ()
L-Cysteine HCl ()
L-Cysteine ()
E920 ()
NSC-8746 ()
Cysteine HCl ()
Cysteinum ()
E921 ()
E 920 ()
FEMA NO. 3263 ()
Cysteine ()
NSC-755898 ()
L-cysteine hydrochloride hydrate ()
L-cysteine ethylester hydrochloride ()
Nouress ()
Cysteine (as hydrochloride) ()
L-cysteine hydrochloride ()
Elcys ()
Cysteine hydrochloride, anhydrous ()
Cysteine hydrochloride anhydrous ()
L-cysteinemethyl hydrochloride ()
Cysteine hydrochloride monohydrate ()
L-Cysteine-15N-d3 ()
P&D ID
PD007726
CAS
52-90-4
7048-04-6
62488-11-3
345909-32-2
4371-52-2
122641-75-2
52-89-1
1795787-05-1
Tags
natural product
drug
available
Approved by
FDA
First approval
1986
Drug Status
nutraceutical
approved
Drug indication
Amino Acid
Non-small-cell lung cancer
Max Phase
Phase 4
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
MOA Cysteine can usually be synthesized by the human body under normal physiological conditions if a sufficient quantity of methionine is available. Cysteine is typically synthesized in the human body when there is sufficient methionine available. Cysteine exhibits antioxidant properties and participates in redox reactions. Cysteine's antioxidant properties are typically expressed in the tripeptide glutathione, which occurs in humans as well as other organisms. Glutathione (GSH) typically requires biosynthesis from its constituent amino acids, cysteine, glycine, and glutamic acid, due to its limited systemic availability. Glutamic acid and glycine are readily available in the diets of most industrialized countries, but the availability of cysteine can be the limiting substrate. In human metabolism, cysteine is also involved in the generation of sulfide present in iron-sulfur clusters and nitrogenase by acting as a precursor. In a 1994 report released by five top cigarette companies, cysteine is one of the 599 additives to cigarettes. Its use or purpose, however, is unknown, like most cigarette additives. Its inclusion in cigarettes could offer two benefits: Acting as an expectorant, since smoking increases mucus production in the lungs; and increasing the beneficial antioxidant glutathione (which is diminished in smokers).
Compound Sets
20
Cayman Chemical Bioactives
33309
34838
ChEMBL Approved Drugs
CHEMBL863
CHEMBL1200630
ChEMBL Drugs
CHEMBL863
CHEMBL1200630
Concise Guide to Pharmacology 2017/18
4782
Concise Guide to Pharmacology 2019/20
4782
Concise Guide to Pharmacology 2021/22
4782
Concise Guide to Pharmacology 2023/24
4782
Drug Repurposing Hub
DrugBank
DB00151
DrugBank Approved Drugs
DB00151
DrugCentral
769
DrugCentral Approved Drugs
769
DrugMAP
DMCMOS8
Guide to Pharmacology
4782
MedChem Express Bioactive Compound Library
HY-Y0337
HY-Y0337A
HY-W016715
NCATS Inxight Approved Drugs
K848JZ4886
NPC Screening Collection
ReFrame library
Selleckchem Bioactive Compound Library
l-cysteine
l-cysteine-hcl
TargetMol Bioactive Compound Library
T2O2721
TN5283
External IDs
95
Properties
(calculated by RDKit )
Molecular Weight
121.02
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
3
Rotatable Bonds
2
Ring Count
0
Aromatic Ring Count
0
cLogP
-0.67
TPSA
63.32
Fraction CSP3
0.67
Chiral centers
1.0
Largest ring
0.0
QED
0.42
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
Metabolism
Apoptosis
Metabolic Enzyme/Protease
Target
Endogenous Metabolite
Ferroptosis
CARS, CARS2, CBS, CDO-1, CDO1, CSAD, CTH, GCLC, GCLM, GOT1, GSS, MGMT, NFS1, SLC19A3
Indication
osteoarthritis, rheumatoid arthritis
Source data