General
Preferred name
CYSTEINE
Synonyms
(R)-CYSTEINE ()
Thioserine ()
L-(+)-Cysteine ()
L-Cysteine hydrochloride monohydrate ()
L-Cysteine HCl ()
L-cysteine ()
L-Cysteine (hydrochloride hydrate) ()
L-Cysteine (hydrochloride) ()
L-Cysteine hydrochloride hydrate ()
L-Cysteine hydrochloride ()
CYSTEINE HYDROCHLORIDE ()
FEMA NO. 3263 ()
L-Cysteine ()
E920 ()
NSC-8746 ()
Cisteina ()
E921 ()
Cysteinum ()
E 920 ()
Cysteine ()
Cysteine HCl ()
Nouress ()
Elcys ()
Cysteine hydrochloride, anhydrous ()
L-cysteine hydrochloride ()
Cysteine (as hydrochloride) ()
Cysteine hydrochloride monohydrate ()
NSC-755898 ()
L-cysteine hydrochloride hydrate ()
Cysteine hydrochloride anhydrous ()
L-Cysteine-15N-d3 ()
P&D ID
PD007726
CAS
7048-04-6
62488-11-3
345909-32-2
4371-52-2
122641-75-2
52-90-4
52-89-1
1795787-05-1
Tags
available
drug
Approved by
FDA
First approval
1986
Drug indication
Non-small-cell lung cancer
Liver disease
Vitamin D deficiency
Drug Status
approved
nutraceutical
Max Phase
4.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
MOA
Cysteine can usually be synthesized by the human body under normal physiological conditions if a sufficient quantity of methionine is available. Cysteine is typically synthesized in the human body when there is sufficient methionine available. Cysteine exhibits antioxidant properties and participates in redox reactions. Cysteine's antioxidant properties are typically expressed in the tripeptide glutathione, which occurs in humans as well as other organisms. Glutathione (GSH) typically requires biosynthesis from its constituent amino acids, cysteine, glycine, and glutamic acid, due to its limited systemic availability. Glutamic acid and glycine are readily available in the diets of most industrialized countries, but the availability of cysteine can be the limiting substrate. In human metabolism, cysteine is also involved in the generation of sulfide present in iron-sulfur clusters and nitrogenase by acting as a precursor. In a 1994 report released by five top cigarette companies, cysteine is one of the 599 additives to cigarettes. Its use or purpose, however, is unknown, like most cigarette additives. Its inclusion in cigarettes could offer two benefits: Acting as an expectorant, since smoking increases mucus production in the lungs; and increasing the beneficial antioxidant glutathione (which is diminished in smokers).
PRICE
29
PRICE
29
DESCRIPTION
L-Cysteine hydrochloride hydrate is an orally active and essential amino acid, which acts as a precursor for biologically active molecules such as hydrogen sulphide (H2S), glutathione and taurine. L-Cysteine hydrochloride hydrate regulates CBS/H2S pathway, inhibits NF-¦ÊB activation and insulin and ghrelin secretion. L-Cysteine hydrochloride hydrate reduces blood sugar, vascular inflammation markers and appetite. L-Cysteine hydrochloride hydrate induces kidney damage. L-Cysteine hydrochloride hydrate can be used in the study of neurological diseases and diabetes[1][2][3][4][5][6][7][8][9].
PRICE
29
DESCRIPTION
Cysteine can usually be synthesized by the human body under normal physiological conditions if a sufficient quantity of methionine is available. It exhibits antioxidant properties and participates in redox reactions. Cysteine is an amino acid commonly found as a component of total parenteral nutrition and used as an antidote for acetaminophen overdose.
(Enamine Bioactive Compounds)
DESCRIPTION
L-Cysteine (L-(+)-Cysteine) is a non-essential sulfur-containing amino acid in humans. L-Cysteine is important for protein synthesis, detoxification, and diverse metabolic functions. Found in beta-keratin, the main protein in nails, skin, and hair, L-Cysteine is important in collagen production, as well as skin elasticity and texture. Also required in the manufacture of amino acid taurine, L-Cysteine is a component of the antioxidant glutathione, and plays a role in the metabolism of essential biochemicals such as coenzyme A, heparin, and biotin.
(TargetMol Bioactive Compound Library)
DESCRIPTION
L-Cysteine hydrochloride (L-Cysteine HCl) is a conditionally essential amino acid,L-Cysteine hydrochloride suppresses ghrelin and reduces appetite in rodents and humans
(TargetMol Bioactive Compound Library)
DESCRIPTION
L-Cysteine hydrochloride hydrate (L-Cysteine hydrochloride monohydrate) is a conditionally essential amino acid, which acts as a precursor for biologically active molecules such as hydrogen sulphide (H2S), taurine and glutathione. L-Cysteine hydrochloride hydrate suppresses ghrelin and reduces appetite in rodents and humans.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
21
ChEMBL Approved Drugs
ChEMBL Drugs
Concise Guide to Pharmacology 2017/18
Concise Guide to Pharmacology 2019/20
Concise Guide to Pharmacology 2021/22
Concise Guide to Pharmacology 2023/24
Drug Repurposing Hub
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMAP
Enamine Bioactive Compounds
Guide to Pharmacology
MedChem Express Bioactive Compound Library
NCATS Inxight Approved Drugs
NPC Screening Collection
ReFrame library
Selleckchem Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
102
Molecular Weight
121.02
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
3
Rotatable Bonds
2
Ring Count
0
Aromatic Ring Count
0
cLogP
-0.67
TPSA
63.32
Fraction CSP3
0.67
Chiral centers
1.0
Largest ring
0.0
QED
0.42
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
Endogenous Metabolite
Ferroptosis
CARS, CARS2, CBS, CDO-1, CDO1, CSAD, CTH, GCLC, GCLM, GOT1, GSS, MGMT, NFS1, SLC19A3
Insulin Receptor
NF-κB
ERK
Pathway
Apoptosis
Metabolism
Metabolic Enzyme/Protease
Protein Tyrosine Kinase/RTK
MAPK/ERK Pathway
Stem Cell/Wnt
NF-¦ÊB
Indication
osteoarthritis, rheumatoid arthritis
Source data
