General
Preferred name
sorbinil
Synonyms
CP-45,634 ()
NSC-355082 ()
Sorbinilo ()
CP-45634 ()
P&D ID
PD007698
CAS
68367-52-2
Tags
available
drug candidate
Drug indication
Diabetic cataract
Diabetic retinopathy
Drug Status
experimental
investigational
Max Phase
3.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Sorbinil is an aldose reductase inhibitor (ARI) that prevents the accumulation of sorbitol in cells or animals. Sorbinil is useful in studying diabetes and diabetic complications, reducing AR activity and inhibiting the polyol pathway[1][2].
PRICE 93
DESCRIPTION Chemical structure is derived from . Sorbinil is an experimental aldose reductase inhibitor. (GtoPdb)
DESCRIPTION Sorbinil is an Aldose reductase inhibitor. Sorbinil plays a therapeutic role in treating diabetes and diabetic complications decreases AR activity and inhibit the polyol pathway. (TargetMol Bioactive Compound Library)
Cell lines
0
Organisms
1
Compound Sets
8
ChEMBL Drugs
CHEMBL266497
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugBank
DB02712
DrugMAP
DM31VE4
Guide to Pharmacology
7415
MedChem Express Bioactive Compound Library
HY-50289
TargetMol Bioactive Compound Library
T16910
External IDs
32
Properties
(calculated by RDKit )
Molecular Weight
236.06
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
2
Rotatable Bonds
0
Ring Count
3
Aromatic Ring Count
1
cLogP
0.64
TPSA
67.43
Fraction CSP3
0.27
Chiral centers
1.0
Largest ring
6.0
QED
0.65
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
Aldose Reductase
AKR1B1
MOA
Aldose reductase inhibitor
Pathway
Endocrinology/Hormones
Metabolism
Metabolic Enzyme/Protease
Source data