General
Preferred name
PROLINE
Synonyms
Proline ()
L-(-)-Proline ()
L-PROLINE ()
Prolina ()
L-2-pyrrolidinecarboxylic acid ()
L-Proline ()
FEMA NO. 3319 ()
NSC-46703 ()
L-Proline-d3 ()
P&D ID
PD007581
CAS
37159-97-0
18875-45-1
4305-67-3
147-85-3
7776-34-3
65807-22-9
Tags
available
drug
Approved by
FDA
Drug indication
Malnutrition
Drug Status
approved
investigational
nutraceutical
Max Phase
2.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PRICE
29
DESCRIPTION
L-Proline (proline) is a nonessential amino acid in humans. It is an essential component of collagen and is important for proper functioning of joints and tendons. It also helps maintain and strengthen heart muscles.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
21
ChEMBL Drugs
Concise Guide to Pharmacology 2017/18
Concise Guide to Pharmacology 2019/20
Concise Guide to Pharmacology 2021/22
Concise Guide to Pharmacology 2023/24
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugBank
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
Guide to Pharmacology
JUMP-Target 1 Compound Set
MedChem Express Bioactive Compound Library
NPC Screening Collection
Other bioactive compounds
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
The Spectrum Collection
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
74
Molecular Weight
115.06
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
2
Rotatable Bonds
1
Ring Count
1
Aromatic Ring Count
0
cLogP
-0.18
TPSA
49.33
Fraction CSP3
0.8
Chiral centers
1.0
Largest ring
5.0
QED
0.5
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
Endogenous Metabolite
EPRS, L3HYPDH, P3H1, P3H2, P3H3, P4HA1, P4HA2, PARS2, PPIA, PPIB, PPIC, PPIF, PPIG, PPIH, PRODH, PROSC, PYCR1, PYCR2, PYCRL, SLC6A14, SLC6A7
P3H1
Apoptosis
MTOR
MOA
glutamate receptor agonist
Therapeutic Class
Dietary supplement
Pathway
Metabolism
Metabolic Enzyme/Protease
PI3K/Akt/mTOR
Source data
