General
Preferred name
PROLINE
Synonyms
Proline ()
L-PROLINE ()
L-(-)-Proline ()
FEMA NO. 3319 ()
L-Proline ()
L-2-pyrrolidinecarboxylic acid ()
Pyrrolidine-2-Carboxylic Acid ()
NSC-46703 ()
L-Proline-d3 ()
P&D ID
PD007581
CAS
147-85-3
37159-97-0
18875-45-1
4305-67-3
7776-34-3
65807-22-9
Tags
natural product
drug
available
Approved by
FDA
Drug indication
Malnutrition
Amino Acid
Drug Status
nutraceutical
approved
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
20
ChEMBL Drugs
Concise Guide to Pharmacology 2017/18
Concise Guide to Pharmacology 2019/20
Concise Guide to Pharmacology 2021/22
Concise Guide to Pharmacology 2023/24
Drug Repurposing Hub
DrugBank
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
Guide to Pharmacology
JUMP-Target 1 Compound Set
MedChem Express Bioactive Compound Library
NPC Screening Collection
Other bioactive compounds
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
The Spectrum Collection
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
69
Properties
(calculated by RDKit )
Molecular Weight
115.06
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
2
Rotatable Bonds
1
Ring Count
1
Aromatic Ring Count
0
cLogP
-0.18
TPSA
49.33
Fraction CSP3
0.8
Chiral centers
1.0
Largest ring
5.0
QED
0.5
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
Metabolism
Metabolic Enzyme/Protease
Target
Endogenous Metabolite
EPRS, L3HYPDH, P3H1, P3H2, P3H3, P4HA1, P4HA2, PARS2, PPIA, PPIB, PPIC, PPIF, PPIG, PPIH, PRODH, PROSC, PYCR1, PYCR2, PYCRL, SLC6A14, SLC6A7
P3H1
MOA
glutamate receptor agonist
Therapeutic Class
Dietary supplement
Source data
