General
Preferred name
FOSMIDOMYCIN
Synonyms
Fosmidomycin sodium salt ()
FR-31564 ()
FOSMIDOMYCIN SODIUM ()
Fosmidomycin (sodium salt) ()
P&D ID
PD007540
CAS
66508-37-0
66508-53-0
Tags
available
natural product
drug
Drug indication
Malaria
Drug Status
experimental
investigational
approved
Max Phase
Phase 3
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Fosmidomycin was first identified as antibiotic but also has antimalarial activity. The compound is under clinical development as a treatment for uncomplicated P. falciparum malaria.

Potential Target/Mechanism Of Action: Fosmidomycin is believed to block the non-mevalonate pathway of isoprenoid biosynthesis by inhibiting the second enzyme in the pathway, 1-deoxy-D-xylulose 5-phosphate reductoisomerase (DXR) .
DESCRIPTION Fosmidomycin was first identified as antibacterial but also has antimalarial activity.

The Malaria tab on this ligand page provides additional curator comments of relevance to the Guide to MALARIA PHARMACOLOGY. (GtoPdb)
Cell lines
0
Organisms
4
Compound Sets
10
Cayman Chemical Bioactives
16000
ChEMBL Drugs
CHEMBL203125
DrugBank
DB02948
DrugMAP
DM7G0EP
DrugMAP Approved Drugs
DM7G0EP
DrugMatrix
Guide to Pharmacology
9739
MedChem Express Bioactive Compound Library
HY-112853
Other bioactive compounds
ReFrame library
External IDs
48
Properties
(calculated by RDKit )
Molecular Weight
183.03
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
3
Rotatable Bonds
5
Ring Count
0
Aromatic Ring Count
0
cLogP
-0.6
TPSA
98.07
Fraction CSP3
0.75
Chiral centers
0.0
Largest ring
0.0
QED
0.23
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Therapeutic Class
Antimalarials
Pathway
Anti-infection
Target
antibiotic
Bacterial
Source data