General
Preferred name
FOSMIDOMYCIN
Synonyms
Fosmidomycin sodium salt ()
FR-31564 ()
Fosmidomycin (sodium salt) ()
FOSMIDOMYCIN SODIUM ()
Fosmidomycine ()
Fosmidomicina ()
P&D ID
PD007540
CAS
66508-37-0
66508-53-0
Tags
natural product
drug
available
Drug indication
Malaria
Drug Status
approved
investigational
experimental
Max Phase
3.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PRICE
90
DESCRIPTION
Fosmidomycin sodium salt (FR-31564 sodium salt) is an anti-infective antibiotic with anti-malarial activity that inhibits both Gram-negative and Gram-positive bacteria.
DESCRIPTION
Fosmidomycin was first identified as antibiotic but also has antimalarial activity. The compound is under clinical development as a treatment for uncomplicated P. falciparum malaria.
Potential Target/Mechanism Of Action: Fosmidomycin is believed to block the non-mevalonate pathway of isoprenoid biosynthesis by inhibiting the second enzyme in the pathway, 1-deoxy-D-xylulose 5-phosphate reductoisomerase (DXR) .
Potential Target/Mechanism Of Action: Fosmidomycin is believed to block the non-mevalonate pathway of isoprenoid biosynthesis by inhibiting the second enzyme in the pathway, 1-deoxy-D-xylulose 5-phosphate reductoisomerase (DXR) .
DESCRIPTION
Fosmidomycin was first identified as antibacterial but also has antimalarial activity.
The Malaria tab on this ligand page provides additional curator comments of relevance to the Guide to MALARIA PHARMACOLOGY. (GtoPdb)
The Malaria tab on this ligand page provides additional curator comments of relevance to the Guide to MALARIA PHARMACOLOGY. (GtoPdb)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
0
Organisms
2
Compound Sets
10
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
50
Molecular Weight
183.03
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
3
Rotatable Bonds
5
Ring Count
0
Aromatic Ring Count
0
cLogP
-0.6
TPSA
98.07
Fraction CSP3
0.75
Chiral centers
0.0
Largest ring
0.0
QED
0.23
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Therapeutic Class
Antimalarials
Pathway
Anti-infection
Target
antibiotic
Bacterial
Source data
